The percent change (PC) in rates over a particular time period is calculated by taking the difference between the average rate of the first two years and the average rate of the last two years. The difference is then divided by the average rate of the first two years and multiplied by 100 to convert it to a percent.

The Annual Percent Change (APC) is calculated by fitting a least squares regression line to the natural logarithm of the rates, using the calendar year as a regressor variable.

*n* = number of years

*r* = rates

*y* = *Ln(r)*

*x* = calendar year

*y* = *mx* + *b*

*APC* = 100 × (*e**m* – 1)

Because the methods used in the calculation of PC and APC are not directly related, it is possible that the signs of the PC and the APC may disagree.

See Calculating APC with Weighting for the formulas used in calculating Weighted APCs.

Testing the hypothesis that the APC is equal to zero is equivalent to testing the hypothesis that the regression parameter m is equal to zero. The hypothesis is rejected at a significance level p if ProbT(abs(m/SEm), n– 2)>= 1– p/2, where ProbT(x,n) is the t distribution function evaluated at x and with n degrees of freedom, and where SEm is the standard error of m from the regression.

The standard error, i.e., SEm, is obtained from the fit of the regression. This calculation assumes that the rates increased or decreased at a constant rate over the entire calendar year interval. The validity of this assumption is not assessed. In those few instances where at least one of the rates is equal to zero, the linear regression is not calculated.

See:

Kleinbaum, Kupper, and Muller. *Applied Regression Analysis and Other Multivariable Methods*. PWS-Kent, Boston, Mass., 2nd edition, 1988.

The endpoints of a p × 100% confidence interval are calculated as:

*CI**Low* = (*e*(*m* – (*Tval* × *SEm*)) – 1) × 100

*CI**High* = (*e*(*m* + (*Tval* × *SEm*)) – 1) × 100

Where Tval = Tinv(1– p/2,n– 2) is the inverse of the t distribution function evaluated at 1– p/2 and with n– 2 degrees of freedom.

Note: In SEER*Stat, you specify the p-value as opposed to the confidence interval. The confidence interval = (1 – p) x 100. Therefore, a 95% confidence interval is specified by p=.05.

The differences between trends for two time periods are tested for statistical significance by comparing the difference in regression coefficients divided by the standard error of that difference with a T distribution with degrees of freedom defined as the sum of the years in both time periods minus 4 (Kleinbaum, 1988).