Acute basophilic leukemia

Name
Acute basophilic leukemia
ICD-O-1 Morphology
9870/3
Effective 1978 - 1991
ICD-O-2 Morphology
9870/3
Effective 1992 - 2000
ICD-O-3 Morphology
9870/3
Effective 2001 and later
Reportable
for cases diagnosed 1978 and later
Primary Site(s)
C421

Help me code for diagnosis year :

Grade
Code grade specified by pathologist. If no grade specified, code 9
Module Rule
M3 Module 5: PH10
Alternate Names
None
Definition
An acute myeloid leukemia in which the primary differentiation is to basophils.

Rare form of acute myeloid leukemia where blasts are accompanied by abnormal basophils in all stages of differentiation.
Abstractor Notes
Cutaneous involvement, organomegaly, lytic lesion, and symptoms relating to hyperhistaminemia may be present. Basophilic leukemia is differentiated from other AML subtypes with basophilia using basophilia immunological markers, light microscopic cytochemistry for myeloperoxidase and electron microscopy.
Definitive Diagnostic Methods
Bone marrow
Immunohistochemistry
Peripheral blood
Genetics Data
No consistent chromosome abnormality
Immunophenotyping
CD11b+
CD13+
CD22+ (possible)
CD33+
CD34 (possible expression)
CD117-
CD123+
CD203c+
HLA-DR+ (possible)
TdT+ (possible)
Treatments
Chemotherapy
Stem cell transplant
Transformations to
There are no known transformations
Transformations from
There are no known transformations
Corresponding ICD-9 Codes
205.1 Chronic myeloid leukemia
Corresponding ICD-10 Codes
C92.1 Chronic myeloid leukemia
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C94.8 Other specified leukemias
Signs and Symptoms
None
Diagnostic Exams
None
Recurrence and Metastases
None
Epidemiology and Mortality
None