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The peripheral blood smear shows neutrophilia and the bone marrow shows hypercellularity but neither are diagnostic of CNL. This is a diagnosis of exclusion; the physician puts together the equivocal test results with the clinical picture and diagnoses CNL.
The peripheral blood and bone marrow are always involved and the spleen and liver usually show leukemic infiltrate; however any tissue may be infiltrated by the neutrophils.
Treatment of CNL focuses on disease control rather than cure. Allogeneic bone marrow transplantation represents a potentially curative treatment modality in the management of this disorder. Varying success has been reported with the use of traditional chemotherapies including hydroxyurea and interferon.
Aspirin was previously documented as treatment for this disease. This was found to be incorrect. Treatment has been updated based on the NCI website (updated 6/12/15)