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9 - Grade/differentiation unknown, not stated, or not applicable
Rare myeloproliferative disease. Sustained peripheral blood neutrophilia, bone marrow hypercellularity due to neutrophilic granulocyte proliferation, and hepatosplenomagaly.
Chronic neutrophilic leukemia (CNL) is very rare. The peripheral blood smear shows neutrophilia and the bone marrow shows hypercellularity but neither are diagnostic of CNL. This is a diagnosis of exclusion; the physician puts together the equivocal test results with the clinical picture and diagnoses CNL. The peripheral blood and bone marrow are always involved and the spleen and liver usually show leukemic infiltrate; however any tissue may be infiltrated by the neutrophils. Treatment focuses on control rather than cure. The patient is usually treated with hydroxyurea.