Chronic lymphocytic leukemia/small lymphocytic lymphoma

Name
Chronic lymphocytic leukemia/small lymphocytic lymphoma
ICD-O-1 Morphology
9823/3
Effective 1978 - 1991
ICD-O-2 Morphology
9823/3
Effective 1992 - 2000
ICD-O-3 Morphology
9823/3
Effective 2001 and later
Reportable
for cases diagnosed 1978 and later
Primary Site(s)
See Abstractor Notes and Module 3: Rules PH5, PH6

Help me code for diagnosis year :

Grade
6 - B-cell
Module Rule
Module 3: PH5, PH6
Alternate Names
All variants of BCLL
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma
Chronic lymphatic leukemia
Chronic lymphocytic leukemia
Chronic lymphocytic leukemia, B-cell type
Chronic lymphoid leukemia
CLL/SLL
SLL/CLL
Definition
CLL by definition involves blood and bone marrow at time of diagnosis with absolute increase in number of lymphocytes in blood morphologically and immunophenotypically consistent with diagnosis.

Neoplasm of monomorphic small round B lymphocytes admixed with prolymphocytes and paraimmunoblasts, in peripheral blood, marrow, nodes, usually expressing CD5, CD23.
Small lymphocytic lymphoma, chronic lymphocytic leukemia considered ends of continuous spectrum in which lymphadenopathy or peripheral blood involvement most prominent, respectively.
Abstractor Notes
Code 9823/3 is used for CLL, SLL, and CLL/SLL. CLL and SLL are no longer coded separately because it is almost impossible to differentiate between the two diseases. See the hematopoietic PH rules for information on coding primary site for CLL/SLL. CLL is the most common leukemia of adults in Western countries. The incidence of CLL is very low in Eastern countries and in immigrants from Eastern countries.

CLL is diagnosed by flow cytometry (immunophenotyping).
Definitive Diagnostic Methods
FISH
Flow cytometry
Histology
Immunophenotyping
Genetics Data
del(13q),del(11q),trisomy12,del(6q)
IG gene rearrangement
Ig heavy and light chain genes rearranged; abnormal karyotypes in 80%:trisomy 2: 20%, del at 13q14 in 50%, del at 11q22-23 in 20%, del at 6q21 in 5%, del at 17p13 in 10%
Tyrone kinase ZAP-70
Immunophenotyping
CD5+
CD10-
CD11c
CD19
CD20
CD22
CD23
CD43
CD79A
Weak or dim surface IgM/IgD
Treatments
Chemotherapy
Hormone
Immunotherapy (Donor lymphocyte infusion)
Transformations from
No Transformations
Corresponding ICD-9 Codes
204.1 Chronic lymphoid leukemia
Corresponding ICD-10 Codes
C91.1 Chronic lymphocytic leukemia
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C91.1 Chronic lymphocytic leukemia of B-cell type
Signs and Symptoms
None
Diagnostic Exams
None
Recurrence and Metastases
None
Epidemiology and Mortality
None