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This is a neoplasm of lymphoblasts committed to the B lineage with a t(1;19) translocation between the E2A(TCF3) gene on chromosome 19 and the PBX1 gene on chromosome 1. This leukemia is relatively common in children, although present in adults as well.
(This code is effective for cases diagnosed 2010 and later. For cases diagnosed prior to 2010 see codes: 9728/3 [lymphomas] or 9836/3 [leukemia].) This neoplasm is relatively common in children accounting for about 6% of cases of B-ALL although adults are also affected.
Definitive Diagnostic Methods
Bone marrow biopsy
CD10+ cytoplasmic heavy chain-positive pre-B-cell phenotype