B lymphoblastic leukemia/lymphoma with t(9;22)(q34;q11.2); BCR-ABL1

Name
B lymphoblastic leukemia/lymphoma with t(9;22)(q34;q11.2); BCR-ABL1
ICD-O-3 Morphology
9812/3
Effective 2010 and later
Reportable
for cases diagnosed 2010 and later
Primary Site(s)
See Abstractor Notes and Module 4: Rules PH7, PH8

Help me code for dx year :

Grade
6 - B-cell
Module Rule
Module 4: PH7, PH8
Alternate Names
None
Definition
This neoplasm is committed to the B-cell lineage in which the blasts harbour a translocation between the BCR gene on chromosome 22 and the ABL1 oncogene on chromosome 9. Presenting factors include increased WBC, but there are otherwise no characteristic clinical findings. Patients with B-ALL may have organ involvement, but lymphomatous presentations are rare.
Abstractor Notes
(This code is effective for cases diagnosed 2010 and later. For cases diagnosed prior to 2010 see codes: 9728/3 [lymphomas] or 9836/3 [leukemia].) This disease occurs in both children and adults. Children usually have a better outcome. This neoplasm is confirmed by immunological markers and/or ultrastructural cytochemistry. Patients present with evidence of BM failure with anemia, thrombocytopenia and neutropenia. Patients with t(9;22) B-ALL may have organ involvement, however lymphomatous presentations are rare.
Definitive Diagnostic Methods
Blood-CBC or peripheral smear
Bone marrow
Genetics testing
Genetics Data
ABL-1 at 9q34
BCR-ABL fusion protein
Fusion of BCR at 22q11.2
p190 kd BCR-ABL1 fusion protein
p210 kd fusion protein
Immunophenotyping
CD10+
CD19+
TdT+
Treatments
Chemotherapy
Stem cell transplant
Transformations to
None
Transformations from
None
Corresponding ICD-9 Codes
204.8 Other lymphoid leukemia
Corresponding ICD-10 Codes
C91.7 Other lymphoid leukemia
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C91.Z Other lymphoid leukemia
Signs and Symptoms
None
Diagnostic Exams
None
Recurrence and Metastases
None
Epidemiology and Mortality
None