This neoplasm is not reportable.
Name
Hemophagocytic syndrome
Reportability
This neoplasm is not reportable
Alternate Names
Definition
Familial hemophagocytic lymphohistiocytosis is a disorder in which the immune system produces too many activated immune cells (lymphocytes) called T cells, natural killer cells, B cells, and macrophages (histiocytes).
Familial hemophagocytic lymphohistiocytosis also destroys blood-producing cells in the bone marrow, a process called hemophagocytosis. As a result, affected individuals have low numbers of red blood cells (anemia) and a reduction in the number of blood cells involved in clotting (platelets). A reduction in platelets may cause easy bruising and abnormal bleeding.
Affected individuals also have an increased risk of developing cancers of blood-forming cells (leukemia and lymphoma).
Familial hemophagocytic lymphohistiocytosis also destroys blood-producing cells in the bone marrow, a process called hemophagocytosis. As a result, affected individuals have low numbers of red blood cells (anemia) and a reduction in the number of blood cells involved in clotting (platelets). A reduction in platelets may cause easy bruising and abnormal bleeding.
Affected individuals also have an increased risk of developing cancers of blood-forming cells (leukemia and lymphoma).
Sources
National Center for Advancing Translational Sciences
Section: Genetic and Rare Disease Information Center
Pages: https://rarediseases.info.nih.gov/diseases/6589/hemophagocytic-lymphohistiocytosis
Section: Genetic and Rare Disease Information Center
Pages: https://rarediseases.info.nih.gov/diseases/6589/hemophagocytic-lymphohistiocytosis