SEER Stat Fact Sheets: Non-Hodgkin Lymphoma

Mortality and lifetime risk have not been updated to include 2011 data (view details).

Statistics at a GlanceShow More

At a Glance

  • Estimated New Cases in 2014 70,800
  • % of All New Cancer Cases4.3%
  • Estimated Deaths in 2014 18,990
  • % of All
    Cancer Deaths
    3.2%

Percent Surviving
5 Years

69.3% 2004-2010

Number of New Cases and Deaths per 100,000: The number of new cases of non-Hodgkin lymphoma was 19.7 per 100,000 men and women per year. The number of deaths was 6.4 per 100,000 men and women per year. These rates are age-adjusted and based on 2007-2011 cases and 2006-2010 deaths.

Lifetime Risk of Developing Cancer: Approximately 2.1 percent of men and women will be diagnosed with non-Hodgkin lymphoma at some point during their lifetime, based on 2008-2010 data.

Prevalence of this cancer: In 2011, there were an estimated 530,919 people living with non-Hodgkin lymphoma in the United States.

Survival StatisticsShow More

How Many People Survive 5 Years Or More after Being Diagnosed with Non-Hodgkin Lymphoma?

Relative survivalExternal Web Site Policy statistics compare the survival of patients diagnosed with cancer with the survival of people in the general population who are the same age, race, and sex and who have not been diagnosed with cancer. Because survival statistics are based on large groups of people, they cannot be used to predict exactly what will happen to an individual patient. No two patients are entirely alike, and treatment and responses to treatment can vary greatly.

69.3%

Percent Surviving
5 Years

69.3%

Based on data from SEER 18 2004-2010. Gray figures represent those who have died from non-Hodgkin lymphoma. Green figures represent those who have survived 5 years or more.

Additional Information

Cancer stage at diagnosis, which refers to extent of a cancer in the body, determines treatment options and has a strong influence on the length of survival. In general, if the cancer is found only in the part of the body where it started it is localized (sometimes referred to as stage 1). If it has spread to a different part of the body, the stage is regional or distant. For non-Hodgkin lymphoma, 27.8% are diagnosed at the local stage. The 5-year survival for localized non-Hodgkin lymphoma is 81.6%.

Percent of Cases & 5-Year Relative Survival by Stage at Diagnosis: Non-Hodgkin Lymphoma
Percent of Cases by Stage
  • Localized (28%)
    Confined to Primary Site
  • Regional (15%)
    Spread to Regional Lymph Nodes
  • Distant (49%)
    Cancer Has Metastasized
  • Unknown (8%)
    Unstaged
28% localized; 15% regional; 49% distant; 8% unknown
5-Year Relative Survival
81.6% localized; 72.9% regional; 61.6% distant; 67.0% unstaged

SEER 18 2004-2010, All Races, Both Sexes by SEER Summary Stage 2000

Additional Information

Number of New Cases and DeathsShow More

How Common Is This Cancer?

Compared to other cancers, non-Hodgkin lymphoma is fairly common.

Common Types of Cancer Estimated New
Cases 2014
Estimated
Deaths 2014
1. Prostate Cancer 233,000 29,480
2. Breast Cancer (Female) 232,670 40,000
3. Lung and Bronchus Cancer 224,210 159,260
4. Colon and Rectum Cancer 136,830 50,310
5. Melanoma of the Skin 76,100 9,710
6. Bladder Cancer 74,690 15,580
7. Non-Hodgkin Lymphoma 70,800 18,990
8. Kidney and Renal Pelvis Cancer 63,920 13,860
9. Thyroid Cancer 62,980 1,890
10. Endometrial Cancer 52,630 8,590

Non-Hodgkin lymphoma represents 4.3% of all new cancer cases in the U.S.

4.3%

In 2014, it is estimated that there will be 70,800 new cases of non-Hodgkin lymphoma and an estimated 18,990 people will die of this disease.

Non-Hodgkin lymphoma is more common in men than women, and among individuals of Caucasian descent. The number of new cases of non-Hodgkin lymphoma was 19.7 per 100,000 men and women per year based on 2007-2011 cases.

Percent of New Cases by Age Group: Non-Hodgkin Lymphoma
1.6% under 20; 3.8% 20-34; 6.2% 35-44; 13.2% 45-54; 20.7% 55-64; 23.1% 65-74; 22.1% 75-84; 9.3% 85 and older

Non-Hodgkin lymphoma is most frequently diagnosed among people aged 65-74.

Median Age
At Diagnosis

66

SEER 18 2007-2011, All Races, Both Sexes

Number of New Cases per 100,000 Persons by Race/Ethnicity & Sex: Non-Hodgkin Lymphoma
MalesFemales
  • Male 23.8All RacesFemale 16.3
  • Male 24.9WhiteFemale 17.1
  • Male 17.4BlackFemale 11.9
  • Male 16.3Asian /
    Pacific Islander
    Female 11.1
  • Male 14.1American Indian /
    Alaska Native
    Female 10.6
  • Male 20.8HispanicFemale 15.6
  • Male 24.4Non-HispanicFemale 16.5

SEER 18 2007-2011, Age-Adjusted

Non-Hodgkin lymphoma is the eighth leading cause of cancer death in the United States. The number of deaths was 6.4 per 100,000 men and women per year based on 2006-2010 deaths.

Percent of Deaths by Age Group: Non-Hodgkin Lymphoma
0.4% under 20; 1.4% 20-34; 2.3% 35-44; 6.6% 45-54; 14.3% 55-64; 22.1% 65-74; 32.8% 75-84; 20.2% 85 and older

The percent of non-Hodgkin lymphoma deaths is highest among people aged 75-84.

Median Age
At Death

76

U.S. 2006-2010, All Races, Both Sexes

Number of Deaths per 100,000 Persons by Race/Ethnicity & Sex: Non-Hodgkin Lymphoma
MalesFemales
  • Male 8.2All RacesFemale 5.1
  • Male 8.5WhiteFemale 5.3
  • Male 5.9BlackFemale 3.6
  • Male 5.2Asian /
    Pacific Islander
    Female 3.4
  • Male 5.4American Indian /
    Alaska Native
    Female 4.3
  • Male 6.5HispanicFemale 4.4
  • Male 8.3Non-HispanicFemale 5.2

U.S. 2006-2010, Age-Adjusted

Trends in RatesShow More

Changes Over Time

Keeping track of the number of new cases, deaths, and survival over time (trends) can help scientists understand whether progress is being made and where additional research is needed to address challenges, such as improving screening or finding better treatments.

Using statistical models for analysis, rates for new non-Hodgkin lymphoma cases have been rising on average 0.5% each year over 2002-2011. Death rates have been falling on average 2.7% each year over 2001-2010. 5-year survival trends are shown below the figure.

More About This CancerShow More

Non-Hodgkin Lymphoma

This picture shows lymph nodes above and below the diaphragm. It also shows the lymph vessels, tonsils, thymus, and spleen.
Figure: Lymph Nodes Above and Below the Diaphragm
Click to enlarge.

The lymphatic system is part of the immune system. The lymphatic system includes lymph vessels that branch into all the tissues of the body; lymph, clear fluid that contains white blood cells, especially lymphocytes such as B cells and T cells; and lymph nodes, where lymph vessels are connected to small, round masses of tissue. Groups of lymph nodes are found in the neck, underarms, chest, abdomen, and groin. Lymph nodes store white blood cells. They trap and remove bacteria or other harmful substances that may be in the lymph.

There are many different types of non-Hodgkin lymphoma. These types can be divided into aggressive (fast-growing) and indolent (slow-growing) types, and they can be formed from either B-cells or T-cells. B-cell non-Hodgkin lymphomas include Burkitt lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), diffuse large B-cell lymphoma, follicular lymphoma, immunoblastic large cell lymphoma, precursor B-lymphoblastic lymphoma, and mantle cell lymphoma. T-cell non-Hodgkin lymphomas include mycosis fungoides, anaplastic large cell lymphoma, and precursor T-lymphoblastic lymphoma.

Other parts of the lymphatic system include the tonsils, thymus, and spleen. Lymphatic tissue is also found in other parts of the body including the stomach, skin, and small intestine. Because lymphatic tissue is in many parts of the body, lymphoma can start almost anywhere. Usually, it's first found in a lymph node.

Additional Information

More Information

Here are some resources for learning more about non-Hodgkin lymphoma.

References

All statistics in this report are based on statistics from SEER and the Centers for Disease Control's National Center for Health Statistics. Most can be found within:

Howlader N, Noone AM, Krapcho M, Garshell J, Neyman N, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Cho H, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.

Suggested Citation

All material in this report is in the public domain and may be reproduced or copied without permission; citation as to source, however, is appreciated.

SEER Cancer Statistics Factsheets: Non-Hodgkin Lymphoma. National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/statfacts/html/nhl.html

This factsheet focuses on population statistics that are based on the US population. Because these statistics are based on large groups of people, they cannot be used to predict exactly what will happen to an individual patient. To see tailored statistics, browse the SEER Cancer Statistics Review. To see statistics for a specific state, go to the State Cancer ProfilesExternal Web Site Policy.

The statistics presented in this factsheet are based on the most recent data available, most of which can be found in the SEER Cancer Statistics Review. In some cases, different year spans may be used. Estimates for the current year are based on past data.

Cancer is a complex topic. There is a wide range of information available. This factsheet does not address causes, symptoms, diagnosis, treatment, follow-up care, or decision making, although it provides links to information in many of these areas.