Question: 20200021

Status


Final

Category


#1:   Solid Tumor Rules (2018)
#2:   Histology
#3:   Head & Neck


References


Source 1:   WHO Class Head and Neck Tumors
pgs:  
Notes:   4th edition
Source 2:  
pgs:  
Notes:  


Question


Solid Tumor Rules/Histology--Head & Neck:  What is the histology of human papillomavirus (HPV)--associated multiphenotypic carcinoma? See Discussion.



Discussion


Histologic Type: HPV-associated multiphenotypic carcinoma. Overall, the morphology, immunohistochemistry, and HPV testing results support the diagnosis of an HPV-related multiphenotypic carcinoma. This entity has been described in the sinonasal region, where it behaves more indolently than its other salivary gland carcinoma counterparts (e.g., adenoid cystic carcinoma), with local recurrence but rare metastases.



Answer


Assign code 8072/3 for HPV-associated multiphenotypic carcinoma.  WHO Classification of Head and Neck Tumors, 4th edition, lists sinonasal tract HPV-related carcinoma with adenoid cystic-like features as a subtype of non-keratinizing squamous cell carcinoma (NKSCC).Use text fields to record the details.



History




Last Updated


05/26/2020

Date Finalized


06/26/2020