CPM

• Lomustine
• Procarbazine
• Methotrexate

Name

Lomustine

Alternate Names

Belustine (nitrosourea)

CeeNu

Chloroethylcyclohexylnitrosourea

ICIG 1109

RB1509

WR-139017

Abbreviations

CCNU

Category

Chemotherapy

Subcategory

Alkylating agent

NSC Number

079037

79037

Primary Site

Brain tumors: primary or metastatic

Hodgkin lymphoma

Non-Hodgkin lymphoma

Histology

None

Remarks

Cell-cycle nonspecific antineoplastic agent;alkylating agent. FDA approved uses in brain tumor and Hodgkin's lymphoma.

Coding

This drug should be coded

Name

Procarbazine

Alternate Names

Ibenzmethyzin Hydrochloride

Matulane

Methylhydrazine

N-Methylhydrazine

Natulan

Natulane

Procarbazine hydrochloride

Ro-4-6467

Ro4-6467/1

Abbreviations

IBZ

MIH

PCB

PCH

PCI

PCZ

Category

Chemotherapy

Subcategory

Nonclassic alkylating agent

NSC Number

077213

77213

Primary Site

Brain tumors adjuvant and/or advanced disease

Cutaneous T-cell lymphoma

Hodgkin lymphoma

Non-Hodgkin lymphoma

Histology

None

Remarks

An orally administered hydrazine derivative antineoplastic agent. FDA approved in stages III, IV Hodgkin's lymphoma.

Coding

This drug should be coded

Name

Methotrexate

Alternate Names

Amethopterin

Antifolan

CL-14377

Folex

Methotrexate Sodium

Mexate

Mexate AQ

Rheumatrex

WR-19039

Abbreviations

MTX

Category

Chemotherapy

Subcategory

Antimetabolite

NSC Number

740

000740

Primary Site

Acute lymphoblastic leukemia (ALL)

Bladder cancer

Breast

Gestational trophoblastic cancer

head & neck cancer

lymphoma

Meningeal leukemia

Non-Hodgkin lymphoma

Osteogenic sarcoma

Primary CNS lymphoma

Histology

None

Remarks

FDA approved uses on ALL, breast cancer, choriocarcinoma, head and neck cancer, lymphoma, and osteosarcoma.

Coding

This drug should be coded