IMF

• Fluorouracil
• Mesna
• Ifosfamide
• Methotrexate

Name

Fluorouracil

Alternate Names

5-Fluorouracil

5-Fluracil

Adrucil

Efudex

Fluoroplex

Fluracil

Fluril

Oracil

Ro 2-9757

WR-69596

Abbreviations

5-FU

5FU

FU

Category

Chemotherapy

Subcategory

Antimetabolite

NSC Number

019893

19893

Primary Site

Breast- adjuvant setting and advanced disease

colorectal- adjuvant setting and advanced disease

GI malignancies: anal, esophageal, gastric and pancreatic

Head and Neck cancer

Hepatoma

Ovarian cancer

Skin-Basal cell carcinoma (topical application)

Histology

None

Remarks

Fluorinated pyrimidine; antimetabolite. FDA approved uses on basal cell carcinoma, breast cancer, colorectal cancer, gastric cancer, and pancreatic cancer.

Note: Efudex cream be prescribed to treat AIN III. Code this as chemotherapy.

Coding

This drug should be coded

Name

Mesna

Alternate Names

D 7093

Mesna rescue

Mesnex

Mesnex uroprotection

Mesnum

Mistabron

Mitexan

Mucofluid

Sodium 2-mercaptoethanolsulfonate

UCB 3983

Uromitexan

Abbreviations

None

Category

Ancillary Agent

Subcategory

None

NSC Number

113891

Primary Site

None

Histology

None

Remarks

A prophylactic detoxifying agent used to inhibit hemorrhagic cystitis caused by ifosfamide. FDA approved for bladder protection when using cyclophosphamide (prevents bladder toxicity).

Coding

This drug should NOT be coded

Name

Ifosfamide

Alternate Names

A-4942

Asta Z-4942

Cyfos#

Holoxan 1000

Ifex

Ifosfamid

Ifoxan

Iphosphamid

Iphosphamide

Iso-endoxan

Isofosfamide

Isophos-phamide

Isophosphamide

Mitoxana

MJF 9325

MJF-9325

Naxamide#

Z4942

Abbreviations

IFX

IPP

Category

Chemotherapy

Subcategory

Alkylating agent

NSC Number

109724

Primary Site

Bladder

Cervical cancer

Ewing sarcoma

Head and Neck

Hodgkin lymphoma

Non-Hodgkin lymphoma

Non-small cell and small cell lung cancer

Soft tissue sarcoma, osteogenic sarcoma

Testicular cancer

Histology

None

Remarks

Antineoplastic with alkylating activity. FDA approved.

Coding

This drug should be coded

Name

Methotrexate

Alternate Names

Amethopterin

Antifolan

CL-14377

Folex

Methotrexate Sodium

Mexate

Mexate AQ

Rheumatrex

WR-19039

Abbreviations

MTX

Category

Chemotherapy

Subcategory

Antimetabolite

NSC Number

740

000740

Primary Site

Acute lymphoblastic leukemia (ALL)

Bladder cancer

Breast

Gestational trophoblastic cancer

head & neck cancer

lymphoma

Meningeal leukemia

Non-Hodgkin lymphoma

Osteogenic sarcoma

Primary CNS lymphoma

Histology

None

Remarks

FDA approved uses on ALL, breast cancer, choriocarcinoma, head and neck cancer, lymphoma, and osteosarcoma.

Coding

This drug should be coded