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Table 28.9

Childhood Cancer

SEER Incidence Rates, U.S. Death Rates and 5-Year Relative Survival Percentages

For Top Cancer Sitesf By 5-Year Age Groups

All Races, Males and Females

Ages 0-4
Site SEER Incidencea US Mortalityb 5-Year Relative Survivala (%)
2006-2010 1975-2010
APC		 1975-1992
APC		 1993-2010
APC		 2006-2010 1975-2010
APC		 1975-1992
APC		 1993-2010
APC		 1975-1977 2003-2009
# Cases Rate # Deaths Rate
All Sites 6,376 22.0 0.8* 1.1* 0.5 2,185 2.2 -2.6* -3.0* -2.0*# 57.2 83.8c
Soft tissue 457 1.6 1.0* 0.8 2.0 115 0.1 -1.9* -1.5 -1.5 62.0d 83.8c
Kidney and Renal pelvis 552 1.9 -0.2 -0.2 -1.6 64 0.1 -3.6* -6.3* -3.1*# 71.9 88.6c
Eye and Orbit 390 1.3 0.2 1.2 -1.7# - - - - - 87.2d 96.9c
Brain and Other nervous 1,206 4.2 1.3* 2.8* 1.2*# 581 0.6 -1.4* -1.3* -2.1* 52.0 74.3c
Other endocrineg 421 1.5 - - - 355 0.4 - - - 35.7d 73.8c
Leukemia 2,387 8.2 0.8* 0.8 0.7 714 0.7 -2.9* -3.7* -1.9*# 55.4 87.5c
Acute lymphocytic 1,942 6.7 0.8* 1.1* 0.7 241 0.2 -4.1* -5.7* -1.7*# 63.2 92.6c
Ages 5-9
Site SEER Incidencea US Mortalityb 5-Year Relative Survivala (%)
2006-2010 1975-2010
APC		 1975-1992
APC		 1993-2010
APC		 2006-2010 1975-2010
APC		 1975-1992
APC		 1993-2010
APC		 1975-1977 2003-2009
# Cases Rate # Deaths Rate
All Sites 3,500 12.3 0.4* 0.8* 0.9* 2,312 2.3 -2.5* -3.3* -1.3*# 58.3 81.0c
Brain and Other nervous 976 3.4 0.5* 1.3 0.8 882 0.9 -0.6* -0.5 0.1 58.4 71.8c
Leukemia 1,165 4.1 0.4 1.7* 0.4 571 0.6 -4.7* -5.4* -3.4*# 51.0 89.1c
Acute lymphocytic 994 3.5 0.7* 1.9* 0.6 317 0.3 -5.3* -6.4* -3.1*# 54.8 94.3c
Ages 10-14
Site SEER Incidencea US Mortalityb 5-Year Relative Survivala (%)
2006-2010 1975-2010
APC		 1975-1992
APC		 1993-2010
APC		 2006-2010 1975-2010
APC		 1975-1992
APC		 1993-2010
APC		 1975-1977 2003-2009
# Cases Rate # Deaths Rate
All Sites 4,021 13.4 0.7* 1.1* 0.5 2,256 2.2 -2.1* -2.5* -1.3*# 58.6 83.9c
Bone and Joint 404 1.4 0.1 1.3 -0.1 238 0.2 -1.4* -3.0* -0.5# 52.8d 81.3c
Brain and Other nervous 779 2.6 0.8* 1.8* -0.5# 626 0.6 -1.2* -1.4* -0.6 59.5 80.2c
Hodgkin lymphoma 365 1.2 -0.8* -0.7 -0.3 - - - - - 78.8 98.7c
Leukemia 970 3.2 0.7* 1.6 1.5* 748 0.7 -2.9* -3.1* -2.6* 34.0 81.7c
Acute lymphocytic 656 2.2 0.9* 2.6* 1.5* 342 0.3 -3.4* -3.3* -3.2* 43.0d 85.6c
Ages 15-19
Site SEER Incidencea US Mortalityb 5-Year Relative Survivala (%)
2006-2010 1975-2010
APC		 1975-1992
APC		 1993-2010
APC		 2006-2010 1975-2010
APC		 1975-1992
APC		 1993-2010
APC		 1975-1977 2003-2009
# Cases Rate # Deaths Rate
All Sites 6,609 21.1 0.5* 1.2* 0.6 3,278 3.0 -2.0* -2.2* -1.9* 67.9 84.5c
Bone and Joint 433 1.4 0.1 0.8 -0.8 539 0.5 -1.1* -2.7* -0.5# 51.0d 68.1c
Melanoma of the skin 356 1.1 1.0* 2.4* 0.4 36 0.0 - - - 76.2d 96.6c
Testis(males) 582 3.6 1.2* 2.1 1.3 29 0.1 - - - 66.0d 95.9c
Brain and Other nervous 642 2.1 0.2 2.1* 0.2@ 509 0.5 -1.3* -1.1* -1.6* 65.3 75.7c
Thyroid 711 2.3 1.7* 1.1 3.2* - - - - - 100.0 98.1
Hodgkin lymphoma 991 3.2 -0.7* 0.3 -0.3 71 0.1 - -3.5* - 89.0 97.1c
Non-Hodgkin lymphoma 546 1.7 1.6* 2.7* 1.3 223 0.2 -2.9* -2.2* -3.4* 47.7d 83.6c
Leukemia 971 3.1 0.7* 0.6 0.7 940 0.9 -2.2* -1.9* -2.6* 23.8 73.9c
Acute lymphocytic 556 1.8 1.1* 1.6 1.6 383 0.3 -2.3* -1.3* -2.6*@ 30.0d 78.2c

Footnotes:

The APC is the Annual Percent Change over the time interval.

Note: Incidence and death rates are per 100,000 and are age-adjusted(as appropriate) to the 2000 US Std Population (19 age groups - Census P25-1130).

a Incidence data used in calculating the rates are from the SEER 18 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, Atlanta, San Jose-Monterey, Los Angeles, Alaska Native Registry, Rural Georgia, California excluding SF/SJM/LA, Kentucky, Louisiana, New Jersey and Georgia excluding ATL/RG).

Incidence data used in calculating the trends and survival estimates are from the 9 SEER areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, and Atlanta).

b US Mortality Files, National Center for Health Statistics, Centers for Disease Control and Prevention.

c The difference between 1975-1977 and 2003-2009 is statistically significant (p<.05).

d The standard error is between 5 and 10 percentage points.

e The standard error is greater than 10 percentage points.

f Sites were chosen based on more than 100 SEER incidence cases between 2006-2010.

g APCs suppressed because of inconsistent classification across ICD: ICD-8 (1975-1978), ICD-9 (1979-1998), ICD-10 (1999-2008).

* The APC is significantly different from zero (p<.05).

# The APC for 1993-2010 is significantly different from the APC for 1975-1992 (p<.05).

@ The APC for 1993-2010 is significantly different from the APC for 1975-1992 (p<.10).

- Statistic not shown. Age-adjusted rate based on less than 16 cases for the time interval. Trend based on less than 10 cases for at least one year within the time interval. Survival rate based on less than 25 cases for the time interval.

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