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Table 28.9

Childhood Cancer

SEER Incidence Rates, U.S. Death Rates and 5-Year Relative Survival Percentages

For Top Cancer Sitesf By 5-Year Age Groups

All Races, Males and Females

Ages 0-4
Site SEER Incidencea US Mortalityb 5-Year Relative Survivala (%)
2007-2011 1975-2011
APC		 1975-1993
APC		 1994-2011
APC		 2007-2011 1975-2011
APC		 1975-1993
APC		 1994-2011
APC		 1975-1977 2004-2010
# Cases Rate # Deaths Rate
All Sites 6,456 22.3 0.7* 1.2* 0.7* 2,155 2.1 -2.6* -2.9* -1.9*# 57.2 84.0c
Soft tissue 476 1.6 1.0* 0.2 1.6 116 0.1 -1.8* -1.7 -1.3 62.0d 85.8c
Kidney and Renal pelvis 570 2.0 -0.1 0.1 -1.2 60 0.1 - -6.1* - 71.9 90.0c
Eye and Orbit 389 1.3 0.2 2.1* -0.4# - - - - - 87.2d 95.8c
Brain and Other nervous 1,201 4.1 1.2* 2.5* 1.1*@ 589 0.6 -1.3* -1.0* -1.5* 52.0 72.5c
Other endocrineg 422 1.5 - - - 345 0.3 - - - 35.7d 76.9c
Leukemia 2,416 8.3 0.8* 0.8* 0.8 676 0.7 -2.9* -3.7* -2.1*# 55.4 88.4c
Acute lymphocytic 1,963 6.8 0.8* 0.9* 0.7 223 0.2 -4.1* -5.7* -2.0*# 63.2 93.0c
Ages 5-9
Site SEER Incidencea US Mortalityb 5-Year Relative Survivala (%)
2007-2011 1975-2011
APC		 1975-1993
APC		 1994-2011
APC		 2007-2011 1975-2011
APC		 1975-1993
APC		 1994-2011
APC		 1975-1977 2004-2010
# Cases Rate # Deaths Rate
All Sites 3,634 12.7 0.5* 0.8* 1.2* 2,294 2.3 -2.5* -3.2* -1.1*# 58.3 81.2c
Brain and Other nervous 992 3.5 0.6* 1.4 1.4* 904 0.9 -0.5* -0.6 0.3@ 58.4 71.4c
Leukemia 1,236 4.3 0.5* 1.5* 0.7 565 0.6 -4.7* -5.3* -3.2*# 51.0 89.2c
Acute lymphocytic 1,058 3.7 0.7* 1.7* 0.8 307 0.3 -5.3* -6.4* -3.4*# 54.8 94.3c
Ages 10-14
Site SEER Incidencea US Mortalityb 5-Year Relative Survivala (%)
2007-2011 1975-2011
APC		 1975-1993
APC		 1994-2011
APC		 2007-2011 1975-2011
APC		 1975-1993
APC		 1994-2011
APC		 1975-1977 2004-2010
# Cases Rate # Deaths Rate
All Sites 4,017 13.5 0.6* 0.9* 0.2@ 2,227 2.1 -2.1* -2.5* -1.5*# 58.6 83.2c
Bone and Joint 420 1.4 0.1 1.0 -0.4 252 0.2 -1.4* -2.8* -0.6# 52.8d 79.3c
Brain and Other nervous 782 2.6 0.7* 1.8* -0.7# 613 0.6 -1.2* -1.6* -0.9* 59.5 80.2c
Hodgkin lymphoma 345 1.2 -0.7* -0.7 -0.1 - - - - - 79.0 97.9c
Leukemia 964 3.2 0.6* 1.1 1.1 723 0.7 -2.9* -3.1* -2.6* 34.0 81.5c
Acute lymphocytic 650 2.2 0.9* 2.0 1.3 349 0.3 -3.3* -3.5* -3.0* 43.0d 84.4c
Ages 15-19
Site SEER Incidencea US Mortalityb 5-Year Relative Survivala (%)
2007-2011 1975-2011
APC		 1975-1993
APC		 1994-2011
APC		 2007-2011 1975-2011
APC		 1975-1993
APC		 1994-2011
APC		 1975-1977 2004-2010
# Cases Rate # Deaths Rate
All Sites 6,763 21.6 0.6* 1.0* 0.7* 3,242 2.9 -1.9* -2.1* -1.8* 67.9 84.3c
Bone and Joint 418 1.3 0.2 0.9 -0.5 525 0.5 -1.1* -2.6* -0.7# 51.0d 70.9c
Melanoma of the skin 353 1.1 0.9* 2.4* 0.1 28 0.0 - - - 76.2d 96.0c
Testis(males) 634 3.9 1.4* 1.8 1.7* 31 0.1 - - - 66.0d 95.4c
Brain and Other nervous 655 2.1 0.1 1.6 -0.2 518 0.5 -1.2* -1.0* -1.2* 65.3 73.7
Thyroid 770 2.5 1.9* 0.8 3.4*# - - - - - 100.0 99.0
Hodgkin lymphoma 995 3.2 -0.6* 0.0 0.0 69 0.1 - -3.9* - 89.0 97.1c
Non-Hodgkin lymphoma 531 1.7 1.5* 2.3* 0.7 210 0.2 -3.0* -2.2* -3.5*@ 47.7d 81.4c
Leukemia 983 3.1 0.8* 0.5 0.8 910 0.8 -2.3* -1.9* -2.5* 23.8 73.0c
Acute lymphocytic 560 1.8 1.2* 1.1 1.7 361 0.3 -2.3* -1.5* -2.8*@ 30.0d 76.6c

Footnotes:

The APC is the Annual Percent Change over the time interval.

Note: Incidence and death rates are per 100,000 and are age-adjusted(as appropriate) to the 2000 US Std Population (19 age groups - Census P25-1130).

a Incidence data used in calculating the rates are from the SEER 18 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, Atlanta, San Jose-Monterey, Los Angeles, Alaska Native Registry, Rural Georgia, California excluding SF/SJM/LA, Kentucky, Louisiana, New Jersey and Georgia excluding ATL/RG).

Incidence data used in calculating the trends and survival estimates are from the 9 SEER areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, and Atlanta).

b US Mortality Files, National Center for Health Statistics, Centers for Disease Control and Prevention.

c The difference between 1975-1977 and 2004-2010 is statistically significant (p<.05).

d The standard error is between 5 and 10 percentage points.

e The standard error is greater than 10 percentage points.

f Sites were chosen based on more than 100 SEER incidence cases between 2007-2011.

g APCs suppressed because of inconsistent classification across ICD: ICD-8 (1975-1978), ICD-9 (1979-1998), ICD-10 (1999-2008).

* The APC is significantly different from zero (p<.05).

# The APC for 1994-2011 is significantly different from the APC for 1975-1993 (p<.05).

@ The APC for 1994-2011 is significantly different from the APC for 1975-1993 (p<.10).

- Statistic not shown. Age-adjusted rate based on less than 16 cases for the time interval. Trend based on less than 10 cases for at least one year within the time interval. Survival rate based on less than 25 cases for the time interval.

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