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Table 28.9

Childhood Cancer

SEER Incidence Rates, U.S. Death Rates and 5-Year Relative Survival Percentages

For Top Cancer Sitesf By 5-Year Age Groups

All Races, Males and Females

Ages 0-4
Site SEER Incidencea US Mortalityb 5-Year Relative Survivala (%)
2008-2012 1975-2012
APC
1975-1993
APC
1994-2012
APC
2008-2012 1975-2012
APC
1975-1993
APC
1994-2012
APC
1975-1977 2005-2011
# Cases Rate # Deaths Rate
All Sites 6,421 22.2 0.7* 1.2* 0.6* 2,174 2.2 -2.5* -2.9* -1.7*# 57.2 84.0c
Soft tissue 490 1.7 1.2* 0.2 2.0 120 0.1 -1.7* -1.7 -1.0 62.0d 81.8c
Kidney and Renal pelvis 546 1.9 -0.3 0.1 -1.6 63 0.1 - -6.1* - 71.9 91.4c
Eye and Orbit 397 1.4 0.2 2.1* -0.2@ 18 0.0 - - - 87.2d 96.0c
Brain and Other nervous 1,184 4.1 1.1* 2.5* 0.7# 587 0.6 -1.3* -1.0* -1.4* 52.0 72.5c
Other endocrineg 415 1.4 - - - 344 0.3 - - - 35.7d 75.9c
Leukemia 2,400 8.3 0.8* 0.8* 0.7 704 0.7 -2.8* -3.7* -1.8*# 55.4 88.6c
Acute lymphocytic 1,919 6.6 0.8* 0.9* 0.5 222 0.2 -4.0* -5.7* -1.9*# 63.2 92.9c
Ages 5-9
Site SEER Incidencea US Mortalityb 5-Year Relative Survivala (%)
2008-2012 1975-2012
APC
1975-1993
APC
1994-2012
APC
2008-2012 1975-2012
APC
1975-1993
APC
1994-2012
APC
1975-1977 2005-2011
# Cases Rate # Deaths Rate
All Sites 3,673 12.7 0.5* 0.8* 1.2* 2,254 2.2 -2.5* -3.2* -1.2*# 58.3 81.7c
Brain and Other nervous 1,012 3.5 0.6* 1.4 1.3* 917 0.9 -0.5* -0.6 0.3# 58.4 72.1c
Leukemia 1,236 4.3 0.5* 1.5* 0.6 523 0.5 -4.6* -5.3* -3.3*# 51.0 87.9c
Acute lymphocytic 1,051 3.6 0.7* 1.7* 0.7 265 0.3 -5.3* -6.4* -3.7*# 54.8 91.2c
Ages 10-14
Site SEER Incidencea US Mortalityb 5-Year Relative Survivala (%)
2008-2012 1975-2012
APC
1975-1993
APC
1994-2012
APC
2008-2012 1975-2012
APC
1975-1993
APC
1994-2012
APC
1975-1977 2005-2011
# Cases Rate # Deaths Rate
All Sites 4,001 13.5 0.6* 0.9* 0.3 2,220 2.1 -2.0* -2.5* -1.3*# 58.6 83.9c
Bone and Joint 430 1.5 0.2 1.0 0.3 252 0.2 -1.4* -2.8* -0.7# 52.8d 76.6c
Brain and Other nervous 766 2.6 0.7* 1.8* -0.8# 634 0.6 -1.1* -1.6* -0.5@ 59.5 79.9c
Hodgkin lymphoma 354 1.2 -0.5 -0.7 0.6 - - - - - 79.0 98.0c
Leukemia 952 3.2 0.6* 1.1 1.0* 674 0.7 -2.9* -3.1* -2.7* 34.0 82.6c
Acute lymphocytic 647 2.2 0.9* 2.0 1.3* 332 0.3 -3.3* -3.5* -3.0* 43.0d 85.6c
Ages 15-19
Site SEER Incidencea US Mortalityb 5-Year Relative Survivala (%)
2008-2012 1975-2012
APC
1975-1993
APC
1994-2012
APC
2008-2012 1975-2012
APC
1975-1993
APC
1994-2012
APC
1975-1977 2005-2011
# Cases Rate # Deaths Rate
All Sites 6,862 22.1 0.6* 1.0* 0.8* 3,197 2.9 -1.9* -2.1* -1.8*@ 67.9 85.0c
Bone and Joint 437 1.4 0.2 0.9 -0.5 524 0.5 -1.1* -2.6* -0.6# 51.0d 71.7c
Melanoma of the skin 332 1.1 0.9* 2.4* 0.1 24 0.0 - - - 76.2d 95.4c
Testis(males) 637 4.0 1.4* 1.8 1.6* 37 0.1 - - - 66.0d 94.9c
Brain and Other nervous 685 2.2 0.2 1.6 0.1 540 0.5 -1.2* -1.0* -1.0* 65.3 75.8c
Thyroid 830 2.7 2.2* 0.7 4.1*# - - - - - 100.0 99.1
Hodgkin lymphoma 984 3.2 -0.5* 0.1 0.2 59 0.1 - -3.9* - 89.0 96.9c
Non-Hodgkin lymphoma 541 1.7 1.4* 2.3* 0.5@ 187 0.2 -3.1* -2.2* -3.9*# 47.7d 82.3c
Leukemia 960 3.1 0.7* 0.5 0.6 864 0.8 -2.3* -1.9* -2.6* 23.8 75.6c
Acute lymphocytic 536 1.7 1.1* 1.1 1.2 346 0.3 -2.3* -1.5* -2.9*@ 30.0d 81.0c

Footnotes:

The APC is the Annual Percent Change over the time interval.

Note: Incidence and death rates are per 100,000 and are age-adjusted(as appropriate) to the 2000 US Std Population (19 age groups - Census P25-1130).

a Incidence data used in calculating the rates are from the SEER 18 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, Atlanta, San Jose-Monterey, Los Angeles, Alaska Native Registry, Rural Georgia, California excluding SF/SJM/LA, Kentucky, Louisiana, New Jersey and Georgia excluding ATL/RG).

Incidence data used in calculating the trends and survival estimates are from the 9 SEER areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, and Atlanta).

b US Mortality Files, National Center for Health Statistics, Centers for Disease Control and Prevention.

c The difference between 1975-1977 and 2005-2011 is statistically significant (p<.05).

d The standard error is between 5 and 10 percentage points.

e The standard error is greater than 10 percentage points.

f Sites were chosen based on more than 100 SEER incidence cases between 2008-2012.

g APCs suppressed because of inconsistent classification across ICD: ICD-8 (1975-1978), ICD-9 (1979-1998), ICD-10 (1999-2008).

* The APC is significantly different from zero (p<.05).

# The APC for 1994-2012 is significantly different from the APC for 1975-1993 (p<.05).

@ The APC for 1994-2012 is significantly different from the APC for 1975-1993 (p<.10).

- Statistic not shown. Age-adjusted rate based on less than 16 cases for the time interval. Trend based on less than 10 cases for at least one year within the time interval. Survival rate based on less than 25 cases for the time interval.

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