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Table 29.3

Age-Adjusted SEER Cancer Incidence Trends, 1975-2012a
By International Classification of Childhood Cancer(ICCC)b Selected Group and Subgroupc
Excluding benign brain and myelodysplastic syndromes
All Races, Males and Females
ICCC Group and Subgroup Ages 0-14 Ages 0-19
% Change APC % Change APC
1975-2012 1975-2012 1975-1993 1994-2012 1975-2012 1975-2012 1975-1993 1994-2012
All ICCC Groups Combined 35.2 0.6* 1.0* 0.7* 36.1 0.6* 1.0* 0.7*
I Leukemia 46.9 0.7* 1.0* 0.8* 40.5 0.7* 0.9* 0.8*
I(a) Lymphoid leukemia 60.1 0.8* 1.1* 0.7 54.9 0.8* 1.1* 0.7*
I(b) Acute myeloid leukemia 69.3 1.1* 1.8* 0.9 55.9 1.1* 1.4* 0.6
II Lymphomas and reticuloendothelial neo. 14.2 0.3 -0.7* 1.7*# 11.5 0.2 0.0 1.0*#
II(a) Hodgkin lymphoma 3.1 -0.6* -1.2 1.2# -3.9 -0.5* -0.4 0.6
II(b,c,e) Non-Hodgkin lymphoma 30.2 0.9* -0.3 2.1*# 41.5 1.1* 0.6 1.5*
III CNS & misc intracranial & intraspinal neo. 36.3 0.9* 2.3* 0.5# 38.0 0.8* 2.1* 0.4#
III(a) Ependymomas and choroid plexus tumors - - - 0.9 - - - 1.0
III(b) Astrocytoma 78.8 1.1* 3.3* 0.8# 68.4 0.8* 2.8* 0.8#
III(c) Intracranial and intraspinal embryonal tum. 65.3 1.0* 1.5 -0.4 84.7 1.1* 1.8 -0.4@
III(d) Other gliomas -45.0 0.5 0.5 0.7 -38.6 0.7* 0.6 0.2
IV Neuroblastoma and other peripheral nervous cell tumors 33.5 0.3 0.6 0.3 36.3 0.3 0.6 0.5
IV(a) Neuroblastoma and ganglioneuroblastoma 33.5 0.4 0.5 0.4 31.4 0.3 0.4 0.4
V Retinoblastoma 11.5 0.2 1.8* -0.3# 11.5 0.2 1.9* -0.4#
VI Renal tumors -14.8 -0.2 0.7 -1.2@ -13.6 -0.1 0.9 -0.9@
VI(a) Nephroblastoma and other nonepithelial renal tumors -15.3 -0.2 0.6 -1.2 -15.3 -0.3 0.7 -1.2@
VII Hepatic tumors - - - - - - - -
VII(a) Hepatoblastoma - - - - - - - -
VIII Malignant bone tumors 73.9 0.2 0.8 0.4 33.9 0.2 0.9 -0.1
VIII(a) Osteosarcoma - - - 0.7 128.8 0.5 1.6* -0.1
VIII(c) Ewing tum. and related sarcomas of bone - - - - -13.6 -0.2 0.4 0.2
IX Soft tissue and other extraosseous sarcomas 54.5 0.8* 0.8 1.1* 54.7 0.7* 0.5 0.8
IX(a) Rhabdomyosarcoma 68.0 0.4 1.3 0.5 64.2 0.4 1.2 0.2
X Germ cell & trophoblastic tum. & neo. of gonads 37.4 1.1* 1.4 0.4 26.4 0.8* 1.5* 0.5
X(a) Intracranial and intraspinal germ-cell tum. - - - - - - - -
X(c) Malignant gonadal germ cell tumors -18.3 - - - 54.7 0.9* 1.3 1.0*
XI Other malignant epithelial neo. and melanomasd 9.0 0.9* 0.4 1.1 83.3 1.2* 0.9 1.9*
XI(b) Thyroid carcinoma 71.6 - - - 206.5 1.9* 0.7 3.9*#
XI(d) Malignant melanoma - - - - 41.9 1.0* 2.1* 0.2

Footnotes:

The APC is the Annual Percent Change over the time interval.

a SEER 9 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, and Atlanta).

b International Classification of Childhood Cancer is based on ICD-O-3. Steliarova-Foucher E, Stiller C, Lacour B, Kaatsch P. International Classification of Childhood Cancer, Third Edition. Cancer. April 1, 2005: Vol 103, No. 7 , pg 1457-1467.

c Classifications are shown for invasive cases only except as noted. For ICCC groups and subgroups that include in situ behavior, only invasive cases are shown except as noted.

d Includes in situ urinary bladder tumors.

* The APC is significantly different from zero (p<.05)

# The APC for 1994-2012 is significantly different from the APC for 1975-1993 (p<.05).

@ The APC for 1994-2012 is significantly different from the APC for 1975-1993 (p<.10).

- Statistic could not be calculated. Trend based on less than 10 cases for at least one year within the time interval.

Neoplasms are abbreviated as neo. Tumors are abbreviated as tum.

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