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Table 30.1

Myelodysplastic Syndromes, Chronic Myeloproliferative Disorders, and Chronic Myelomonocytic Leukemia

Counts, Percents and Age-Adjusted Incidence Ratesa by Subtype

18 SEER Geographic Areas 2008-2012

All Myelodysplastic syndromes (MDS),
Chronic myeloproliferative disorders (CMD),
Chronic myelomonocytic leukemia (CMML)
Site Both Sexes Males Females
Count Percent Rate Count Percent Rate Count Percent Rate
Total 34,431 100.0% 8.0 18,802 100.0% 10.3 15,629 100.0% 6.4
Myelodysplastic Syndromes (MDS)
Site Both Sexes Males Females
Count Percent Rate Count Percent Rate Count Percent Rate
Myelodysplastic Syndromes (MDS) 21,056 100.0% 5.0 11,879 100.0% 6.8 9,177 100.0% 3.7
Refractory anemia (RA), NOS 1,856 8.8% 0.4 968 8.1% 0.6 888 9.7% 0.4
RA with ringed sideroblasts 1,378 6.5% 0.3 782 6.6% 0.4 596 6.5% 0.2
RA with excess blasts (RAEB) 2,871 13.6% 0.7 1,717 14.5% 0.9 1,154 12.6% 0.5
RAEB in transformation 54 0.3% 0.0 34 0.3% 0.0 20 0.2% 0.0
Refractory cytopenia w/multilineage dysplasia 1,482 7.0% 0.4 975 8.2% 0.5 507 5.5% 0.2
Myelodysplastic syndrome with 5q deletion 634 3.0% 0.1 261 2.2% 0.1 373 4.1% 0.2
Therapy-related myelodysplastic syndrome 291 1.4% 0.1 156 1.3% 0.1 135 1.5% 0.1
Myelodysplastic syndrome, NOS 12,490 59.3% 2.9 6,986 58.8% 4.0 5,504 60.0% 2.2
Chronic Myeloproliferative Disorders (CMD)
Site Both Sexes Males Females
Count Percent Rate Count Percent Rate Count Percent Rate
Chronic Myeloproliferative Disorders (CMD) 11,581 100.0% 2.6 5,783 100.0% 2.9 5,798 100.0% 2.4
Polycythemia vera 4,406 38.0% 1.0 2,461 42.6% 1.2 1,945 33.5% 0.8
Chronic myeloproliferative disease, NOS 1,011 8.7% 0.2 547 9.5% 0.3 464 8.0% 0.2
Myelosclerosis with myeloid metaplasia 1,447 12.5% 0.3 878 15.2% 0.5 569 9.8% 0.2
Essential thrombocythemia 4,539 39.2% 1.0 1,781 30.8% 0.9 2,758 47.6% 1.2
Chronic neutrophilic leukemia 30 0.3% 0.0 23 0.4% 0.0 - - -
Hypereosinophilic syndrome 148 1.3% 0.0 93 1.6% 0.0 55 0.9% 0.0
Chronic Myelomonocytic Leukemia (CMML)
Site Both Sexes Males Females
Count Percent Rate Count Percent Rate Count Percent Rate
Chronic Myelomonocytic Leukemia (CMML) 1,794 100.0% 0.4 1,140 100.0% 0.6 654 100.0% 0.3

Footnotes:

Source: SEER 18 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, Atlanta, San Jose-Monterey, Los Angeles, Alaska Native Registry, Rural Georgia, California excluding SF/SJM/LA, Kentucky, Louisiana, New Jersey and Georgia excluding ATL/RG).

a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130).

- Statistic not shown due to fewer than 16 cases during the time period.

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