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Table 29.3

Age-Adjusted SEER Cancer Incidence Trends, 1975-2017a
By International Classification of Childhood Cancer(ICCC)b Selected Group and Subgroupc
Excluding benign brain and myelodysplastic syndromes
All Races, Males and Females

ICCC Group and Subgroup Ages 0-14 Ages 0-19
% Change APC % Change APC
1975-2017 1975-2017 1975-1996 1997-2017 1975-2017 1975-2017 1975-1996 1997-2017
All ICCC Groups Combined 38.4 0.6* 0.7* 0.6* 39.6 0.7* 0.7* 0.8*
I Leukemia 62.7 0.7* 0.7* 0.6* 58.0 0.7* 0.6* 0.7*
I(a) Lymphoid leukemia 76.6 0.7* 0.9* 0.5 70.7 0.7* 0.9* 0.5
I(b) Acute myeloid leukemia 85.5 1.1* 1.4* 0.8 70.7 1.0* 1.3* 0.6
II Lymphomas and reticuloendothelial neo. -13.2 0.3* -0.8* 1.1* -1.6 0.3* -0.1 1.0*
II(a) Hodgkin lymphoma -18.4 -0.5* -1.3* 0.2 -26.8 -0.5* -0.6 0.2
II(b,c,e) Non-Hodgkin lymphoma -3.1 1.1* -0.2 1.9* 42.4 1.3* 0.8* 1.9*
III CNS & misc intracranial & intraspinal neo. 49.9 0.7* 1.6* 0.2 51.4 0.7* 1.5* 0.4
III(a) Ependymomas and choroid plexus tumors 144.8 0.9* 1.9 1.5* 162.2 1.0* 1.9 1.8*
III(b) Astrocytoma 56.2 0.8* 2.1* 0.4 56.0 0.7* 1.7* 0.8
III(c) Intracranial and intraspinal embryonal tum. 193.2 0.8* 1.8* -0.4 211.2 0.8* 1.9* -0.5
III(d) Other gliomas -19.9 0.4 -0.3 -0.3 -9.8 0.6* 0.3 -0.1
IV Neuroblastoma and other peripheral nervous cell tumors 1.7 0.3 0.4 0.2 1.7 0.3 0.4 0.3
IV(a) Neuroblastoma and ganglioneuroblastoma -1.7 0.3 0.4 0.2 -1.6 0.3 0.3 0.3
V Retinoblastoma 16.5 0.3 0.9 -0.1 16.5 0.3 1.0 -0.1
VI Renal tumors 26.9 0.0 0.6 -0.1 27.6 0.1 0.7 0.0
VI(a) Nephroblastoma and other nonepithelial renal tumors 23.2 -0.1 0.6 -0.1 32.0 -0.1 0.6 0.0
VII Hepatic tumors 203.9 2.2* 2.1 1.5 285.5 2.1* 2.0 1.3
VII(a) Hepatoblastoma 428.5 2.5* 3.2* 1.5 428.5 2.4* 3.1* 1.6
VIII Malignant bone tumors 52.4 0.4 0.9 0.9 20.2 0.3 1.0* 0.3
VIII(a) Osteosarcoma 216.5 0.9* 1.8* 1.5 96.5 0.6* 1.7* 0.8
VIII(c) Ewing tum. and related sarcomas of bone -9.7 -0.1 -0.4 1.0 -9.1 -0.1 0.3 0.1
IX Soft tissue and other extraosseous sarcomas 26.9 0.5* 0.6 0.3 48.5 0.6* 0.6 0.1
IX(a) Rhabdomyosarcoma 0.0 0.1 0.9 0.1 20.3 0.1 0.8 -0.3
X Germ cell & trophoblastic tum. & neo. of gonads 50.5 0.9* 1.8* 0.6 19.5 0.6* 1.3* 0.3
X(a) Intracranial and intraspinal germ-cell tum. 88.0 - - 0.3 105.6 1.7* 4.6* 0.5
X(c) Malignant gonadal germ cell tumors 11.4 0.1 -0.8 0.4 26.2 0.6* 1.0* 0.0
XI Other malignant epithelial neo. and melanomasd 81.0 1.7* 0.2 3.1* 103.4 1.6* 0.7 2.8*
XI(b) Thyroid carcinoma 59.6 1.8* -0.1 3.8* 166.1 2.4* 0.4 4.3*
XI(d) Malignant melanoma 5.5 1.5* 0.7 0.4 10.8 0.6* 1.4 -1.3

Footnotes:

The APC is the Annual Percent Change over the time interval.

a SEER 9 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, and Atlanta).

b International Classification of Childhood Cancer is based on ICD-O-3. International Classification of Childhood Cancer is based on ICD-O-3. Steliarova-Foucher E, Colombet M, Ries LAG, Moreno F, Dolya A, Shin HY, Hesseling P, Stiller CA. International Incidence of Childhood Cancer, Volume III. Lyon: International Agency for Research on Cancer, In press.

c Classifications are shown for invasive cases only except as noted. For ICCC groups and subgroups that include in situ behavior, only invasive cases are shown except as noted.

d Includes in situ urinary bladder tumors.

* The APC is significantly different from zero (p<.05)

# The APC for 1997-2017 is significantly different from the APC for 1975-1996 (p<.05).

@ The APC for 1997-2017 is significantly different from the APC for 1975-1996 (p<.10).

- Statistic could not be calculated. Trend based on less than 10 cases for at least one year within the time interval.

Neoplasms are abbreviated as neo. Tumors are abbreviated as tum.

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