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Table 2.3

Age-Adjusted SEER Cancer Incidence Trends, 1975-2018a
By International Classification of Childhood Cancer(ICCC)b Selected Group and Subgroupc
Excluding benign brain and myelodysplastic syndromes
All Races, Males and Females

ICCC Group and Subgroup Ages 0-14 Ages 0-19
% Change APC % Change APC
1975-2018 1975-2018 1975-1996 1997-2018 1975-2018 1975-2018 1975-1996 1997-2018
All ICCC Groups Combined 46.3 0.8* 0.8* 0.9* 43.4 0.8* 0.8* 1.0*
I Leukemia 48.0 0.8* 0.8* 0.7* 45.3 0.8* 0.7* 0.8*
I(a) Lymphoid leukemia 68.1 0.7* 0.9* 0.4 65.8 0.7* 0.9* 0.5*
I(b) Acute myeloid leukemia 24.4 1.0* 1.6* 0.5 16.4 0.9* 1.4* 0.4
II Lymphomas and reticuloendothelial neo. 44.4 1.2* -0.9* 3.3*# 28.3 0.7* -0.1 2.2*#
II(a) Hodgkin lymphoma -8.4 -0.5* -1.5* 0.3# -11.7 -0.5* -0.6 0.3@
II(b,c,e) Non-Hodgkin lymphoma
III CNS & misc intracranial & intraspinal neo. 69.2 0.7* 1.9* 0.3# 63.5 0.7* 1.7* 0.5#
III(a) Ependymomas and choroid plexus tumors 195.4 1.0* 2.3* 1.7* 185.5 1.1* 2.2* 1.8*
III(b) Astrocytoma 62.0 0.8* 2.5* 0.3# 57.4 0.7* 2.1* 0.7#
III(c) Intracranial and intraspinal embryonal tum. 183.4 0.8* 1.8* -0.3# 184.6 0.8* 1.9* -0.4#
III(d) Other gliomas 20.7 0.5 0.1 0.3 27.5 0.7* 0.7 0.5
IV Neuroblastoma and other peripheral nervous cell tumors 17.7 0.3 0.5 0.3 20.7 0.3* 0.6 0.4
IV(a) Neuroblastoma and ganglioneuroblastoma 12.6 0.3 0.5 0.2 14.1 0.3 0.4 0.3
V Retinoblastoma -3.9 0.2 1.2 -0.2 -3.9 0.2 1.2 -0.2
VI Renal tumors 30.2 0.0 0.5 -0.1 28.0 0.1 0.6 -0.1
VI(a) Nephroblastoma and other nonepithelial renal tumors 23.8 -0.1 0.5 -0.2 23.8 -0.1 0.5 -0.2
VII Hepatic tumors 270.1 2.1* 2.2 1.3 372.1 2.1* 2.0 1.2
VII(a) Hepatoblastoma 560.8 2.4* 3.4* 1.4 560.8 2.3* 3.3* 1.4
VIII Malignant bone tumors 48.6 0.3 0.6 0.8 11.0 0.2 0.7 0.1
VIII(a) Osteosarcoma 139.7 0.8* 1.5* 1.3 57.0 0.6* 1.4* 0.6
VIII(c) Ewing tum. and related sarcomas of bone 18.5 -0.2 -0.7 0.8 -3.8 -0.2 -0.1 -0.1
IX Soft tissue and other extraosseous sarcomas 16.4 0.5* 0.6 0.2 18.8 0.5* 0.5 -0.2
IX(a) Rhabdomyosarcoma -0.3 0.1 1.0 -0.2 -4.1 0.0 0.9 -0.6
X Germ cell & trophoblastic tum. & neo. of gonads 37.8 0.9* 1.8* 0.5 12.4 0.6* 1.4* 0.1#
X(a) Intracranial and intraspinal germ-cell tum. 69.3 - - 0.2 69.4 1.6* 4.5* 0.3#
X(c) Malignant gonadal germ cell tumors 18.5 0.1 -0.8 0.6 31.3 0.6* 1.2* -0.2#
XI Other malignant epithelial neo. and melanomasd 71.2 1.8* 0.4 3.0*# 111.6 1.6* 0.8* 2.8*#
XI(b) Thyroid carcinoma 119.0 1.8* 0.0 3.8*# 223.1 2.5* 0.7 4.3*#
XI(d) Malignant melanoma 31.4 1.4* 1.2 0.1 30.4 0.5 1.8* -1.4#

Footnotes:

The APC is the Annual Percent Change over the time interval.

a SEER 9 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, and Atlanta).

b International Classification of Childhood Cancer is based on ICD-O-3. International Classification of Childhood Cancer is based on ICD-O-3. Steliarova-Foucher E, Colombet M, Ries LAG, Moreno F, Dolya A, Shin HY, Hesseling P, Stiller CA. International Incidence of Childhood Cancer, Volume III. Lyon: International Agency for Research on Cancer, In press.

c Classifications are shown for invasive cases only except as noted. For ICCC groups and subgroups that include in situ behavior, only invasive cases are shown except as noted.

d Includes in situ urinary bladder tumors.

* The APC is significantly different from zero (p<.05)

# The APC for 1997-2018 is significantly different from the APC for 1975-1996 (p<.05).

@ The APC for 1997-2018 is significantly different from the APC for 1975-1996 (p<.10).

- Statistic could not be calculated. Trend based on less than 10 cases for at least one year within the time interval.

Neoplasms are abbreviated as neo. Tumors are abbreviated as tum.

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