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Table 2.4
Age-Adjusted SEER Cancer Incidence Trends, 1975-2018a
By International Classification of Childhood Cancer(ICCC)b Selected Group and Subgroupc
Excluding benign brain and myelodysplastic syndromes
All Races, Males
| ICCC Group and Subgroup | Ages 0-14 | Ages 0-19 | ||||||
|---|---|---|---|---|---|---|---|---|
| % Change | APC | % Change | APC | |||||
| 1975-2018 | 1975-2018 | 1975-1996 | 1997-2018 | 1975-2018 | 1975-2018 | 1975-1996 | 1997-2018 | |
| All ICCC Groups Combined | 46.8 | 0.8* | 1.0* | 0.9* | 44.9 | 0.8* | 1.0* | 0.9* |
| I Leukemia | 40.0 | 0.8* | 0.9* | 0.7* | 38.9 | 0.8* | 0.7* | 0.8* |
| I(a) Lymphoid leukemia | 57.9 | 0.7* | 1.2* | 0.4 | 61.0 | 0.7* | 1.1* | 0.5 |
| I(b) Acute myeloid leukemia | 46.5 | 1.2* | 1.9* | 0.5 | 29.7 | 1.0* | 1.1 | 0.2 |
| II Lymphomas and reticuloendothelial neo. | 45.4 | 1.1* | -1.1* | 3.4*# | 25.6 | 0.8* | -0.3 | 2.5*# |
| II(a) Hodgkin lymphoma | 5.1 | -0.6 | -1.8 | 0.7# | -25.2 | -0.5* | -0.9 | 0.6# |
| II(b,c,e) Non-Hodgkin lymphoma | ||||||||
| III CNS & misc intracranial & intraspinal neo. | 97.8 | 0.7* | 2.2* | 0.2# | 77.7 | 0.6* | 2.0* | 0.3# |
| III(a) Ependymomas and choroid plexus tumors | 305.4 | 0.8 | 2.0 | 2.1* | 305.4 | 0.8* | 2.0 | 2.0* |
| III(b) Astrocytoma | 88.2 | 0.6* | 2.7* | 0.3# | 71.3 | 0.5* | 2.1* | 0.6# |
| III(c) Intracranial and intraspinal embryonal tum. | 333.0 | 0.6 | 2.0* | -0.6# | 299.0 | 0.6* | 2.1* | -0.8# |
| III(d) Other gliomas | 21.2 | 0.6 | 0.7 | 0.0 | 20.4 | 0.7* | 1.4 | 0.4 |
| IV Neuroblastoma and other peripheral nervous cell tumors | 11.7 | 0.3 | 1.1 | 0.6 | 14.8 | 0.3 | 1.3 | 0.7 |
| IV(a) Neuroblastoma and ganglioneuroblastoma | 8.0 | 0.3 | 1.1 | 0.5 | 11.2 | 0.3 | 1.1 | 0.6 |
| V Retinoblastoma | 13.5 | 0.4 | 1.8 | -0.2 | 13.5 | 0.4 | 1.9 | -0.2 |
| VI Renal tumors | 50.2 | -0.1 | 1.1 | -0.2 | 40.8 | 0.0 | 1.0 | -0.3 |
| VI(a) Nephroblastoma and other nonepithelial renal tumors | 57.6 | -0.2 | 1.2 | -0.4 | 57.6 | -0.2 | 1.1 | -0.3 |
| VII Hepatic tumors | 63.8 | 2.0* | 3.7* | 0.7 | 200.7 | 2.0* | 3.5* | 0.7 |
| VII(a) Hepatoblastoma | 145.8 | 2.2* | 4.3* | 0.8@ | 145.8 | 2.2* | 4.6* | 1.0# |
| VIII Malignant bone tumors | 19.5 | 0.5 | 1.2 | 0.3 | 16.9 | 0.4 | 1.5* | -0.1 |
| VIII(a) Osteosarcoma | 139.5 | 0.9* | 1.7 | 0.9 | 140.8 | 0.7* | 2.2* | 0.4 |
| VIII(c) Ewing tum. and related sarcomas of bone | -7.3 | 0.0 | 0.1 | -0.5 | -28.5 | 0.0 | 0.3 | -0.6 |
| IX Soft tissue and other extraosseous sarcomas | 28.2 | 0.7* | 0.7 | 0.6 | 32.8 | 0.7* | 0.6 | 0.2 |
| IX(a) Rhabdomyosarcoma | 12.0 | 0.1 | 1.3 | 0.1 | 10.4 | 0.0 | 0.9 | -0.2 |
| X Germ cell & trophoblastic tum. & neo. of gonads | 3.1 | 0.6 | 1.9 | -0.6 | 46.0 | 0.8* | 1.7* | -0.1# |
| X(a) Intracranial and intraspinal germ-cell tum. | 15.9 | - | - | -0.9 | 37.1 | 1.6* | 4.7* | 0.1# |
| X(c) Malignant gonadal germ cell tum. (testis) | -34.5 | -0.5 | -1.0 | -1.1 | 49.9 | 0.7* | 1.0 | -0.3 |
| XI Other malignant epithelial neo. and melanomasd | 70.3 | 1.7* | 0.4 | 3.0*# | 121.3 | 1.6* | 0.9 | 2.6*# |
| XI(b) Thyroid carcinoma | 446.7 | - | - | 5.6* | 344.5 | 2.6* | -1.1 | 5.5*# |
| XI(d) Malignant melanoma | -53.5 | 1.3* | 0.3 | 0.8 | -17.0 | 0.5 | 2.1 | -1.4# |
Footnotes:
The APC is the Annual Percent Change over the time interval.
a SEER 9 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, and Atlanta).
b International Classification of Childhood Cancer is based on ICD-O-3. International Classification of Childhood Cancer is based on ICD-O-3. Steliarova-Foucher E, Colombet M, Ries LAG, Moreno F, Dolya A, Shin HY, Hesseling P, Stiller CA. International Incidence of Childhood Cancer, Volume III. Lyon: International Agency for Research on Cancer, In press.
c Classifications are shown for invasive cases only except as noted. For ICCC groups and subgroups that include in situ behavior, only invasive cases are shown except as noted.
d Includes in situ urinary bladder tumors.
* The APC is significantly different from zero (p<.05)
# The APC for 1997-2018 is significantly different from the APC for 1975-1996 (p<.05).
@ The APC for 1997-2018 is significantly different from the APC for 1975-1996 (p<.10).
- Statistic could not be calculated. Trend based on less than 10 cases for at least one year within the time interval.
Neoplasms are abbreviated as neo. Tumors are abbreviated as tum.
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