<< Historical Staging and Coding Manuals

Appendix C brings together the site-specific instructions needed to abstract a case, facilitating efficiency and accuracy. The site-specific coding modules include SEER Coding Guidelines, Extent of Disease, and Surgery of Primary Site codes.1

New for 2021 are the Site-Specific Neoadjuvant Therapy Effect coding documents. Links to the applicable coding document(s) have been added to each site in Appendix C.

General instructions in the main manual are applicable in the absence of site-specific instructions. All modules include the extent of disease and surgery codes, and solid tumor coding rules. Some modules include site-specific coding guidelines. Additional site-specific coding instructions are found in SEER*RSA, the SSDI manualExternal Web Site Policy (PDF), and the Grade manualExternal Web Site Policy (PDF).

Oral Cavity, Tonsil, Oropharynx

Parotid, Other and Unspecified Glands

Pharynx, Hypopharynx, Nasopharynx, Pyriform Sinus



Small Intestine

Colon, Appendix, Rectosigmoid, Rectum


Liver, Intrahepatic Bile Ducts

Gallbladder, Extrahepatic Bile Ducts, Ampulla of Vater


Gastrointestinal Stromal Tumors

Other Digestive

Nasal Cavity, Middle Ear, Sinuses


Trachea, Other Respiratory


Heart, Mediastinum, Pleura

Bones, Joints, Cartilage



Mycosis Fungoides, Sezary Disease

Soft Tissues, Nerves, Nervous System

Retroperitoneum, Peritoneum


Vulva, Vagina

Cervix Uteri

Corpus Uteri, Uterus, NOS


Fallopian Tube, Ligaments, Adnexa

Other and Unspecified Female Genital Organs, Placenta




Other and Unspecified Male Genital Organs


Renal Pelvis, Ureter


Urethra, Urinary Other


Brain, Central Nervous System, Malignant

Brain, Central Nervous System, Benign and Borderline


Thymus, Adrenal and Other Endocrine Glands

Kaposi Sarcoma


Hematopoietic, Reticuloendothelial, Immunoproliferative and Myeloproliferative

Other and Unknown Sites

1The surgery codes are based on the American College of Surgeons Commission on Cancer's Standards for Oncology Registry Entry, American College of Surgeons, Chicago, IL, 60611-321 (STORE), Revised for 2021, Appendix B: Site-specific Surgery Codes. The surgery codes in this document are identical to the STORE manual; only formatting and annotations may vary. The SEER Notes that appear in the Surgery Code sections contain information or instructions not found in STORE or that are different from STORE.

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