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Table 30.1

Myelodysplastic Syndromes, Chronic Myeloproliferative Disorders, and Chronic Myelomonocytic Leukemia

Counts, Percents and Age-Adjusted Incidence Ratesa by Subtype

21 SEER Geographic Areas 2013-2017

All Myelodysplastic syndromes (MDS),
Chronic myeloproliferative disorders (CMD),
Chronic myelomonocytic leukemia (CMML)

Site Both Sexes Males Females
Count Percent Rate Count Percent Rate Count Percent Rate
Total 52,474 100.0% 8.1 28,465 100.0% 10.2 24,009 100.0% 6.6

Myelodysplastic Syndromes (MDS)

Site Both Sexes Males Females
Count Percent Rate Count Percent Rate Count Percent Rate
Myelodysplastic Syndromes (MDS) 28,032 100.0% 4.3 16,238 100.0% 6.0 11,794 100.0% 3.2
Refractory anemia (RA), NOS 1,300 4.6% 0.2 710 4.4% 0.3 590 5.0% 0.2
RA with ringed sideroblasts 1,574 5.6% 0.2 898 5.5% 0.3 676 5.7% 0.2
RA with excess blasts (RAEB) 4,582 16.3% 0.7 2,815 17.3% 1.0 1,767 15.0% 0.5
RAEB in transformation - - - - - - - - -
Refractory cytopenia w/multilineage dysplasia 2,172 7.7% 0.3 1,425 8.8% 0.5 747 6.3% 0.2
Myelodysplastic syndrome with 5q deletion 1,076 3.8% 0.2 429 2.6% 0.2 647 5.5% 0.2
Therapy-related myelodysplastic syndrome - - - - - - - - -
Myelodysplastic syndrome, NOS 17,328 61.8% 2.7 9,961 61.3% 3.7 7,367 62.5% 2.0

Chronic Myeloproliferative Disorders (CMD)

Site Both Sexes Males Females
Count Percent Rate Count Percent Rate Count Percent Rate
Chronic Myeloproliferative Disorders (CMD) 21,268 100.0% 3.3 10,222 100.0% 3.4 11,046 100.0% 3.1
Polycythemia vera 8,718 41.0% 1.3 4,886 47.8% 1.6 3,832 34.7% 1.1
Chronic myeloproliferative disease, NOS - - - - - - - - -
Myelosclerosis with myeloid metaplasia 2,375 11.2% 0.4 1,399 13.7% 0.5 976 8.8% 0.3
Essential thrombocythemia 9,940 46.7% 1.5 3,789 37.1% 1.3 6,151 55.7% 1.8
Chronic neutrophilic leukemia 54 0.3% 0.0 33 0.3% 0.0 21 0.2% 0.0
Hypereosinophilic syndrome 181 0.9% 0.0 115 1.1% 0.0 66 0.6% 0.0

Chronic Myelomonocytic Leukemia (CMML)

Site Both Sexes Males Females
Count Percent Rate Count Percent Rate Count Percent Rate
Chronic Myelomonocytic Leukemia (CMML) 3,174 100.0% 0.5 2,005 100.0% 0.7 1,169 100.0% 0.3

Footnotes:

Source: SEER 21 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, Atlanta, San Jose-Monterey, Los Angeles, Alaska Native Registry, Rural Georgia, California excluding SF/SJM/LA, Kentucky, Louisiana, New Jersey, Georgia excluding ATL/RG, Idaho, New York and Massachusetts).

a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130).

- Statistic not shown due to fewer than 16 cases during the time period.

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