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Table 1.1

Estimated New Cancer Cases and Deaths for 2021
All Races, By Sex

Primary Site Estimated New Cases Estimated Deaths
Both Sexes Males Females Both Sexes Males Females
All Sites 1,898,160 970,250 927,910 608,570 319,420 289,150
Oral Cavity and Pharynx 54,010 38,800 15,210 10,850 7,620 3,230
Tongue 17,960 13,040 4,920 2,870 1,930 940
Mouth 14,290 8,400 5,890 2,650 1,520 1,130
Pharynx 18,470 14,990 3,480 3,870 3,060 810
Other Oral Cavity 3,290 2,370 920 1,460 1,110 350
Digestive System 338,090 191,090 147,000 169,280 98,140 71,140
Esophagus 19,260 15,310 3,950 15,530 12,410 3,120
Stomach 26,560 16,160 10,400 11,180 6,740 4,440
Small Intestine 11,390 6,130 5,260 2,100 1,110 990
Colona 104,270 52,590 51,680 52,980 28,520 24,460
Rectum 45,230 26,930 18,300
Anus, Anal Canal, and Anorectum 9,090 3,020 6,070 1,430 560 870
Liver and Intrahepatic Bile Duct 42,230 29,890 12,340 30,230 20,300 9,930
Gallbladder and Other Biliary 11,980 5,730 6,250 4,310 1,770 2,540
Pancreas 60,430 31,950 28,480 48,220 25,270 22,950
Other Digestive 7,650 3,380 4,270 3,300 1,460 1,840
Respiratory System 254,170 132,910 121,260 137,040 73,340 63,700
Larynx 12,620 9,940 2,680 3,770 3,020 750
Lung and Bronchus 235,760 119,100 116,660 131,880 69,410 62,470
Other Respiratory 5,790 3,870 1,920 1,390 910 480
Bones and Joints 3,610 2,100 1,510 2,060 1,190 870
Soft Tissue 13,460 7,720 5,740 5,350 2,840 2,510
Skin (excl. basal & squamous) 115,320 68,120 47,200 11,540 7,660 3,880
Melanoma of the Skinb 106,110 62,260 43,850 7,180 4,600 2,580
Other non-epithelial skin 9,210 5,860 3,350 4,360 3,060 1,300
Breastb 284,200 2,650 281,550 44,130 530 43,600
Genital Organs 376,970 260,210 116,760 69,110 35,030 34,080
Cervix (uterus) 14,480   14,480 4,290   4,290
Endometrium (uterus) 66,570   66,570 12,940   12,940
Ovary 21,410   21,410 13,770   13,770
Vulva 6,120   6,120 1,550   1,550
Vagina and other genital organs, female 8,180   8,180 1,530   1,530
Prostate 248,530 248,530   34,130 34,130
Testis 9,470 9,470   440 440
Penis and other genital organs, male 2,210 2,210   460 460
Urinary System 164,000 115,750 48,250 31,940 21,640 10,300
Urinary Bladder 83,730 64,280 19,450 17,200 12,260 4,940
Kidney and Renal Pelvis 76,080 48,780 27,300 13,780 8,790 4,990
Ureter and other urinary organs 4,190 2,690 1,500 960 590 370
Eye and Orbit 3,320 1,750 1,570 400 220 180
Brain and Other Nervous System 24,530 13,840 10,690 18,600 10,500 8,100
Endocrine System 47,200 13,730 33,470 3,290 1,620 1,670
Thyroid 44,280 12,150 32,130 2,200 1,050 1,150
Other Endocrine 2,920 1,580 1,340 1,090 570 520
Lymphoma 90,390 50,460 39,930 21,680 12,740 8,940
Hodgkin Lymphoma 8,830 4,830 4,000 960 570 390
Non-Hodgkin Lymphoma 81,560 45,630 35,930 20,720 12,170 8,550
Myeloma 34,920 19,320 15,600 12,410 6,840 5,570
Leukemia 61,090 35,530 25,560 23,660 13,900 9,760
Acute lymphocytic leukemia 5,690 3,000 2,690 1,580 900 680
Chronic lymphocytic leukemia 21,250 13,040 8,210 4,320 2,620 1,700
Acute myeloid leukemia 20,240 11,230 9,010 11,400 6,620 4,780
Chronic myeloid leukemia 9,110 5,150 3,960 1,220 680 540
Other leukemia 4,800 3,110 1,690 5,140 3,080 2,060
All Other Sitesc 32,880 16,270 16,610 47,230 25,610 21,620

Footnotes:

Cancer Facts & Figures – 2021, American Cancer Society (ACS), Atlanta, Georgia, 2021. Excludes basal and squamous cell skin and in situ carcinomas except urinary bladder.

Estimated new cases are based on 2003-2017 incidence rates reported by the North American Association of Central Cancer Registries (NAACCR).

Estimated deaths are based on 2004-2018 US mortality data, National Center for Health Statistics, Centers for Disease Control and Prevention.

a Estimated deaths for colon & rectum cancers are combined.

b Carcinoma in situ of the breast accounts for about 49,290 new cases annually, and melanoma in situ accounts for about 101,280 new cases annually.

c More deaths than cases suggests lack of specificity in recording underlying causes of death on death certificate.

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