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Rate Exercise 3: Merged Variables

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Define groupings based on two or more variables in the database.

Merged variables are created by defining groupings from one, two, or more variables in the database. Up to this point, we have been using user-defined variables based on groupings from a single standard variable to stratify our results, but in some cases it is impossible to get the exact groupings needed based on one variable. See the example below which illustrates the need for merged variables.

Exercise

Use a merged variable to create a table showing five age-adjusted incidence rates for:

  • Breast cancer among women ages less than 50
  • Breast cancer among women ages 50 and older
  • Prostate cancer for men ages less than 65
  • Prostate cancer for men ages 65 and older
  • Lung and bronchus cancer (both sexes, all ages)

These rates should be age-adjusted to the 2000 U.S. standard population and should be based on malignant cases diagnosed from 2000 through 2021 in the 22 SEER registries.

Key Points

This sample output (Matrix 3a) (sim, 28.5 KB) is provided as an illustration, you do not need to create that matrix. It is shown to illustrate the need for SEER*Stat's "merged variables". The problem can be done correctly using the steps in the next section.

  • A user-defined variable is an edited version of a single standard variable in the database. Merged variables are user-defined variables based on one or more variables.
  • Merged variables are typically used for stratifying results by groupings that require variables such as site and histology; or site and extent of disease fields.
  • You can use standard user-defined variables to calculate the statistics for this problem. However, the matrix will contain other unwanted and possibly misleading statistics (like the rate for prostate cancer for both sexes in the sample output).
  • If you are not using merged variables, two user-defined variables must be created. (see results matrix 3a (sim, 28.5 KB)). These are: an age variable with 5 groupings (all ages, <50, 50+, <65, 65+); and a cancer site variable with three groupings (lung and bronchus, breast, prostate). The results are displayed for every combination of these variables and sex.
  • In this exercise we will create a variable based on cancer site, sex, and age. The variable will have groupings for the five groupings listed above ("Lung and Bronchus Cancer for All Ages, Both Sexes", "Prostate Cancer for Men Age <65", etc).

Instructions

Step 1:  Create a Rate Session

  1. Start SEER*Stat.
  2. Start a new Rate Session from New Session menu.

Step 2:  Select a Database

  1. On the Select Database dialog, select "Incidence - SEER Research Limited-Field Data, 22 Registries, Nov 2023 Sub (2000-2021)" and press the OK button.
  2. When you select the SEER 22 Registries database in a rate session, a warning dialog appears with a linked database alert that the database contains data from several sources. A link for more information is provided. Note that the warning has a checkbox labeled, Do not show this message in future. Mark this checkbox to prevent this warning from being displayed in future sessions. If you have done so in the past, it will not be displayed now. Press the OK button on the warning dialog, if it opened.
  3. Make sure the Age Variable is set to "Age recode with < 1 year olds".

Step 3:  Choose the Statistics to Display

  1. Select Statistic from the sidebar menu.
  2. In the Statistic box, select Rates (Age-Adjusted).
  3. In the Parameters box, verify that:
    • Standard Population is set to "2000 US Std Population (19 age groups - Census P25-1130)".
    •  Age Variable is set to "Age recode with < 1 year olds"

Step 4:  Define the Analysis Cohort

For this problem you should create a selection statement based on cancer site. The system will process the data more efficiently if you specify the cancer sites as Selection options rather than relying on the definitions of variables used on the Table options. Specific click-by-click instructions for creating individual selection statements were given in previous tutorials (see Frequency Exercise 1a). Use those techniques to create three selection statements. Be sure to consider each box on the Selection options in order as you review the problem statement.

  1. Move to the Selection options.
  2. Make sure that the Malignant Behavior is checked in the Select Only box. The Known Age option is always checked and disabled in rate sessions because all records must have values that are included in the U.S. Population and Standard Population data. Unknown age is not a valid value, so records with unknown ages are excluded from the analysis.
  3. Make the following selections in the Other (Case Files) box: {Site and Morphology.Site recode ICD-O-3/WHO 2008} = 'Lung and Bronchus','Breast','Prostate'

Step 5:  Create a Merged Variable

Use the Dictionary editor to create a merged variable with five groupings: Breast Cancer (females, <50), Breast Cancer (females, 50+), Prostate Cancer (males, age <65), Prostate Cancer (males, 65+), Lung and Bronchus Cancer (all ages, both sexes).

  1. Open the Dictionary editor by selecting the Dictionary button from the Actions menu.
  2. Click the Merge button to open the Edit Merged Variable window.
  3. Enter the following name for the merged variable in the Name field: "Breast, Prostate, Lung (by age, sex)"
  4. Click the Add button to open the New Merged Grouping dialog. Notice that the New Merged Grouping dialog is the same as the Case Selection dialog used to define your analysis cohort on the Selection options. Selection statements are used to define the groupings of a merged variable.
  5. Add the first grouping (Breast Cancer - females, <50) by creating a selection statement for the subset of cases the new grouping will contain. You must use three variables to define the breast cancer grouping, Site recode ICD-O-3/WHO 2008, Age recode with <1 year olds, and Sex. Your selection statement should look like this:
    {Age at Diagnosis.Age recode with <1 year olds} = '00 years','01-04 years','05-09 years','10-14 years','15-19 years','20-24 years','25-29 years','30-34 years','35-39 years','40-44 years','45-49 years'
    And {Race, Sex, Year Dx.Sex} = ' Female'
    And {Site and Morphology.Site recode ICD-O-3/WHO 2008} = ' Breast'
  6. Click the OK button on the New Merged Grouping dialog to return to the Edit Merged Variable dialog.
  7. Give a meaningful name to your new grouping, such as "Breast (females, <50)", since it will be the label used as the headers in your output matrix.
  8. Click the Add button and repeat these steps to create the four additional groupings needed for this exercise:
    Breast (females, 50+)
    {Age at Diagnosis.Age recode with <1 year olds} = '50-54 years','55-59 years','60-64 years','65-69 years','70-74 years','75-79 years','80-84 years','85+ years'
    And {Race, Sex, Year Dx.Sex} = ' Female'
    And {Site and Morphology.Site recode ICD-O-3/WHO 2008} = ' Breast'

    Prostate (males, <65)
    {Age at Diagnosis.Age recode with <1 year olds} = '00 years','01-04 years','05-09 years','10-14 years','15-19 years','20-24 years','25-29 years','30-34 years','35-39 years','40-44 years','45-49 years','50-54 years','55-59 years','60-64 years'
    And {Race, Sex, Year Dx.Sex} = ' Male'
    And {Site and Morphology.Site recode ICD-O-3/WHO 2008} = ' Prostate'

    Prostate (males, 65+)
    {Age at Diagnosis.Age recode with <1 year olds} = '65-69 years','70-74 years','75-79 years','80-84 years','85+ years'
    And {Race, Sex, Year Dx.Sex} = ' Male'
    And {Site and Morphology.Site recode ICD-O-3/WHO 2008} = ' Prostate'

    Lung (both sexes, all ages)
    {Site and Morphology.Site recode ICD-O-3/WHO 2008} = ' Lung and Bronchus'

    The lung and bronchus grouping should be defined using only the Site recode ICD-O-3/WHO 2008 variable. There is no need to use the age or sex variables to define this grouping since we are showing the lung and bronchus rate for all ages and both sexes.
  9. When you have finished defining the merged variable, press the OK button to close the Edit Merged Variable dialog. Notice that a new folder has been added to the dictionary named "Merged".
  10. Close the dictionary and add your new merged variable as a Row variable on the Table options.

See the Edit Merged Variable Dialog topic for more information

Step 6:  Specify a Title

  1. Move to the Output options.
  2. Enter the following title:
SEER 22 Incidence, 2000-2021
Rate Exercise 3b (merged variables)

Step 7:  Execute SEER*Stat

  1. Execute the Session.
  2. Compare your results to this SEER*Stat matrix file: Rate Exercise 3 Results Matrix (sim, 23.4 KB). 
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