Myeloid and lymphoid neoplasms with PDGFRA rearrangement
Help me code for diagnosis year :
This disease is associated with PDGFRA rearrangement that is associated with FIP1L1-PDGFRA formed as a result of a cryptic deletion at 4q12.
Presentation is generally as chronic eosinophilic leukemia (CEL) but can be acute myeloid leukemia (AML) as well.
This is a multi-system disorder. Peripheral blood and bone marrow are always involved.
Tissue infiltration by eosinophils can lead to tissue damage in the heart, lungs, central and peripheral nervous system, skin and GI tract.