Myeloid and lymphoid neoplasms with FGFR1 abnormalities
Help me code for diagnosis year :
This disease is derived from a pluripotent hematopoietic stem cell. Patients can present as lymphoma with mainly lymph node involvement, or with myeloproliferative features, such as splenomegaly, AML or myeloid sarcoma.
Myeloid and lymphoid neoplasms associated FGFR1 abnormalities primarily involve the bone marrow, peripheral blood, lymph nodes, liver and spleen. Lymphadenopathy is the result of infiltration by lymphoblasts or myeloid cells.
There is no established tyrosine kinase inhibitor therapy for MPN with FGFR1 rearrangement.
Interferon has induced a cytogenetic response in several patients. Until specific therapy is developed, hematopoietic stem cell transplantation should be considered even in those who present in chronic phase.