Myeloid leukemia associated with Down Syndrome
Help me code for diagnosis year :
Individuals with DS have a 50x increase in incidence of acute leukemia during the first 5 years of life compared to non-DS individuals. This is part of the myeloid proliferations with Down syndrome WHO group, which also includes transient abnormal myelopoiesis (see 9898/1).
This disease is unique to children with Down's Syndrome (DS). Blood and bone marrow are the principle sites of involvement. Extramedullary involvement, mainly of spleen and liver, is almost always present.
There is no biological differences between myelodysplastic syndrome (MDS) and overt acute myeloid leukemia (AML) in DS individuals. Because this type of disease is unique to children with DS, the term Myeloid leukemia (AML) of DS encompasses both neoplasms, MDS and AML.
If the leukemia occurs before or simultaneously with Myeloid Sarcoma, see M3 and Module 5: PH10