Mixed phenotype acute leukemia with t(v;11q23); MLL rearranged

Name
Mixed phenotype acute leukemia with t(v;11q23); MLL rearranged
ICD-O-3 Morphology
9807/3
Effective 2010 and later
Reportable
for cases diagnosed 2010 and later
Primary Site(s)
C421
Primary site must be bone marrow (C421)

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Grade
9 - Grade/differentiation unknown, not stated, or not applicable
Module Rule
None
Alternate Names
MLL
Definition
The blasts in this leukemia have a translocation involving the mixed lineage leukemia (MLL) gene. High white blood cell counts are common.
Abstractor Notes
(This code is effective for cases diagnosed 2010 and later. For cases diagnosed prior to 2010 see code 9801/3.)

This is a rare leukemia that is more common in children than in adults. Patients with B/myeloid leukemia with MLL translocations are often treated differently from patients diagnosed with ALL with MLL translocations, but there is no evidence that the difference in treatment is necessary or helpful.
Definitive Diagnostic Methods
Bone marrow biopsy
FISH
Genetic testing
Immunophenotyping
Polymerase chain reaction (PCR)
Genetics Data
AF4 on chromosome 4 band q21
Immunophenotyping
CD10-
CD15+
CD19+
Treatments
Chemotherapy
Stem cell transplant
Transformations to
There are no known transformations
Transformations from
There are no known transformations
Corresponding ICD-9 Codes
208.0 Acute leukemia of unspecified cell type
Corresponding ICD-10 Codes
C95.0 Acute leukemia of unspecified cell type
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C95.0 Acute leukemia of unspecified cell type
Signs and Symptoms
Bone or joint pain
Easy bruising or bleeding
Eczema-like skin rash
Fatigue
Fever
High white blood cell counts
Night sweats
Pain or feeling of fullness below the ribs
Painless lumps
Petechiae
Shortness of breath
Weakness
Recurrence and Metastases
None
Epidemiology and Mortality
Age: more common in children, especially infancy
Incidence: rare
Survival: poor prognosis