Mixed phenotype acute leukemia, B/myeloid, NOS

Name
Mixed phenotype acute leukemia, B/myeloid, NOS
ICD-O-3 Morphology
9808/3
Effective 2010 and later
Reportable
for cases diagnosed 2010 and later
Primary Site(s)
C421
Primary site must be bone marrow (C421)

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Grade
9 - Grade/differentiation unknown, not stated, or not applicable
Module Rule
None
Alternate Names
None
Definition
This leukemia meets criteria for assignment to both B and myeloid lineage as in 9807 (mixed phenotype acute leukemia with t(v;11q23) MLL rearranged), but the blasts lack the genetic abnormalities seen in 9807. Most cases have blasts with no distinguishing features, morphologically resembling ALL, or have dimorphic populations with one resembling lymphoblasts and the other resembling myeloblasts.
Abstractor Notes
(This code is effective for cases diagnosed 2010 and later. For cases diagnosed prior to 2010 see code 9801/3.)

There are no unique clinical features for this leukemia. Although the leukemia meets the criteria for both B and myeloid lineages, the blasts lack the B and myeloid genetic abnormalities.
Definitive Diagnostic Methods
Bone marrow biopsy
Genetic testing
Immunophenotyping
Genetics Data
12p11.2 abnormalities
del(5q)
del(6p)
Numerical abnormalities including near tetraploidy
Structural abnormalities of 7
Immunophenotyping
CD13+
CD33+
CD117+
Treatments
Chemotherapy
Transformations to
There are no known transformations
Transformations from
There are no known transformations
Corresponding ICD-9 Codes
208.0 Acute leukemia of unspecified cell type
Corresponding ICD-10 Codes
C95.0 Acute leukemia of unspecified cell type
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C95.0 Acute leukemia of unspecified cell type
Signs and Symptoms
Bone or joint pain
Easy bruising or bleeding
Eczema-like skin rash
Night sweats
Pain or feeling of fullness below the ribs
Painless lumps
Shortness of breath
Weakness
Progression and Transformation
None
Epidemiology and Mortality
Age: more common in adults (can occur in children)
Incidence: <1% of all Leukemia cases