Mixed phenotype acute leukemia, B/myeloid, NOS

Name
Mixed phenotype acute leukemia, B/myeloid, NOS
ICD-O-3 Morphology
9808/3
Effective 2010 and later
Reportable
for cases diagnosed 2010 and later
Primary Site(s)
C421

Help me code for diagnosis year :

Grade
9 - Grade/differentiation unknown, not stated, or not applicable
Module Rule
None
Alternate Names
None
Definition
This leukemia meets criteria for assignment to both B and myeloid lineage as in 9807 (mixed phenotype acute leukemia with t(v;11q23) MLL rearranged), but the blasts lack the genetic abnormalities seen in 9807. Most cases have blasts with no distinguishing features, morphologically resembling ALL, or have dimorphic populations with one resembling lymphoblasts and the other resembling myeloblasts.
Abstractor Notes
(This code is effective for cases diagnosed 2010 and later. For cases diagnosed prior to 2010 see code 9801/3.) This leukemia is very rare; probably accounts for about 1% of leukemias. It is more common in adults, but is also seen in children. There are no unique clinical features for this leukemia. Although the leukemia meets the criteria for both B and myeloid lineages, the blasts lack the B and myeloid genetic abnormalities.
Definitive Diagnostic Methods
Bone marrow biopsy AND
Genetics testing
Immunophenotyping
Genetics Data
12p11.2 abnormalities
del(5q)
del(6p)
Numerical abnormalities including near tetraploidy
Structural abnormalities of 7
Immunophenotyping
CD13+
CD33+
CD117+
Treatments
Chemotherapy
Transformations to
No Transformations
Transformations from
No Transformations
Corresponding ICD-9 Codes
208.0 Acute leukemia of unspecified cell type
Corresponding ICD-10 Codes
C95.0 Acute leukemia of unspecified cell type
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C95.0 Acute leukemia of unspecified cell type
Signs and Symptoms
None
Diagnostic Exams
None
Recurrence and Metastases
None
Epidemiology and Mortality
None