SEER is an authoritative source of information on cancer incidence and survival in the United States. SEER currently collects and publishes cancer incidence and survival data from population-based cancer registries covering approximately 28 percent of the U.S. population.
Peripheral T-cell lymphoma characterized by systemic disease; a polymorphous infiltrate involving lymph nodes, with a prominent proliferation of high endothelial venules and follicular dendritic cells.
AITL typically presents with advanced stage disease, with spleen, liver, skin and bone marrow frequently involved.
Patients exhibit immunodeficiency secondary to the neoplastic process, in the majority of cases the expansion of B-cells positive for EBV is seen, thought to be a consequence of underlying immune dysfunction.
Aggressive clinical course with patients often succumbing to infectious complications, which makes delivery of aggressive chemotherapy difficult.