Name

Malignant lymphoma, NOS

ICD-O-1 Morphology

9590/3: Malignant lymphoma, NOS
9601/3: Malignant lymphoma, stem cell type
9603/3: Stem cell lymphoma
Effective 1978 - 1991

ICD-O-2 Morphology

9590/3: Malignant lymphoma, NOS
9594/3: Microglioma
Effective 1992 - 2000

ICD-O-3 Morphology

9590/3: Malignant lymphoma, NOS
Effective 2001 and later

Reportable

for cases diagnosed 1978 and later

Primary Site(s)

See Abstractor Notes and Module 7

Abstractor Notes

This NOS histology is a generic disease description. DCO cases or path report only cases may stay in this classification. In most cases, an NOS histology is only the working diagnosis; the physician will run further diagnostic procedures and look for various clinical presentations to identify a more specific disease.

Further review of the medical record should be performed to look for the tests listed as definitive diagnosis. When a more specific diagnosis is identified, the histology should be changed to the more specific neoplasm name and code.

For 9590/3 malignant lymphoma, NOS, non-Hodgkin lymphoma, classical Hodgkin lymphoma, and any specific Hodgkin and non-Hodgkin lymphomas would be a more specific histology.

See the histology tables (Appendix B of the Hematopoietic manual) for more information on NOS and more specific histologies.

Diagnostic Confirmation

This is a histology for which the Definitive Diagnostic Method does not include Genetics Data or Immunophenotyping, thus Diagnostic Confirmation should never be 3. If genetics and/or immunophenotyping are available, re-review to see if a more specific neoplasm can be coded.

Grade

Not Applicable

Module Rule

None

Alternate Names

Lymphoma, NOS
Microglioma ( C71_) [OBS]

Definition

General term for a group of cancers that originate in the lymphatic system. Unable to determine if Hodgkin or non-Hodgkin type. This is not a commonly used pathology term.

Definitive Diagnostic Methods

Clinical diagnosis
Histologic confirmation

Genetics Data

None

Immunophenotyping

None

Treatments

Chemotherapy
Hematologic Transplant and/or Endocrine Procedures
Hormone therapy
Radiation therapy
Surgery

Transformations to

There are no known transformations

Transformations from

There are no known transformations

Same Primaries

Corresponding ICD-9 Codes

202.8 Other lymphoma

Corresponding ICD-10 Codes

C85.9 Non-Hodgkin lymphoma, unspecified type

Corresponding ICD-10-CM Codes (U.S. only)

C85.9 Non-Hodgkin lymphoma, unspecified (effective October 01, 2015)
C85.8 Other specified types of non-Hodgkin lymphoma (effective October 01, 2015)

Signs and Symptoms

None

Diagnostic Exams

None

Progression and Transformation

None

Epidemiology and Mortality

None

Sources

International Classification of Diseases for Oncology, Third Edition, Second Revision. Geneva: World Health Organization, 2020
Section: ICD-O-3.2 (2020) Morphological Codes
Pages: http://www.iacr.com.fr/index.php?option=com_content&view=category&layout=blog&id=100&Itemid=577

National Cancer Institute
Section: Lymphoma
Pages: https://www.cancer.gov/types/lymphoma/hp
Glossary