B lymphoblastic leukemia/lymphoma with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1)

Name
B lymphoblastic leukemia/lymphoma with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1)
ICD-O-3 Morphology
9814/3
Effective 2010 and later
Reportable
for cases diagnosed 2010 and later
Primary Site(s)
See Module 4: Rules PH7, PH8
Usually presents as a leukemia. Lymphomatous presentation is rare.

Help me code for diagnosis year :

Grade
6 - B-cell
Module Rule
Module 4: PH7, PH8
Alternate Names
None
Definition
A neoplasm of lymphoblasts committed to the B lineage with a translocation between the TEL (ETV6) gene on chromosome 12 with the AML1(RUNX1) gene on chromosome 12.
Abstractor Notes
(This code is effective for cases diagnosed 2010 and later. For cases diagnosed prior to 2010, see codes: 9728/3 [lymphoma] or 9836/3 [leukemia].)

This leukemia is relatively common in children. The incidence decreases with age, so it is seldom seen in older children and rarely, if never, in adults.
Definitive Diagnostic Methods
Bone marrow biopsy
Genetic testing
Immunophenotyping
Genetics Data
t(12;21)(p13;q22); ETV6-RUNX1 translocation
Immunophenotyping
CD9-
CD10+
CD19+
CD20-
CD34+
CD66c-
Treatments
Chemotherapy
Stem cell transplant
Transformations to
There are no known transformations
Transformations from
There are no known transformations
Corresponding ICD-9 Codes
204.8 Other lymphoid leukemia
Corresponding ICD-10 Codes
C91.7 Other lymphoid leukemia
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C91.Z Other lymphoid leukemia
Signs and Symptoms
Anemia
Arthralgias
Bone pain
Hepatomegaly
Splenomegaly
Diagnostic Exams
CT (CAT) scan
Cytogenetic analysis
Complete blood count (CBC)
Laparoscopy (rarely performed)
Laparotomy (rarely performed)
MRI (magnetic resonance imaging)
PET (positron emission tomography) scan
Recurrence and Metastases
None
Epidemiology and Mortality
Age: most common in children (not seen in infants, rare in adulthood)
Incidence: 25% of cases of B-ALL
Survival: favorable prognosis, >90% cure of children