SEER is an authoritative source of information on cancer incidence and survival in the United States. SEER currently collects and publishes cancer incidence and survival data from population-based cancer registries covering approximately 28 percent of the U.S. population.
A neoplasm of lymphoblasts committed to the B lineage that harbours a translocation between the MLL gene at band 11q23 and any one of a large number of different fusion partners. Patients with leukemias that have deletions of 11q23 without MLL rearrangements are not included in this group. Patients present with very high white blood cell counts. There is a high frequency of CNS involvement at diagnosis.
(This code is effective for cases diagnosed 2010 and later. For cases diagnosed prior to 2010 see codes: 9728/3 [lymphomas] or 9836/3 [leukemia].) The specific etiology of leukemia with MLL translocations is unknown; however, it may occur in utero, with a short latency between the translocation and development of disease. Evidence for this statement includes the fact that these leukemias are frequent in very young infants. This is the most common leukemia for children less than 1 yr old.