B lymphoblastic leukemia/lymphoma, NOS

Name
B lymphoblastic leukemia/lymphoma, NOS
ICD-O-3 Morphology
9811/3
Effective 2010 and later
Reportable
for cases diagnosed 2010 and later
Primary Site(s)
See Abstractor Notes and Module 4: Rules PH7, PH8

Help me code for diagnosis year :

Grade
6 - B-cell
Module Rule
Module 4: PH7, PH8
Alternate Names
ALL
Acute lymphoblastic leukemia
B-ALL
B-LBL
B lymphoblastic leukemia/lymphoma, not otherwise specified
Definition
A neoplasm of precursor cells (lymphoblasts) committed to the B-cell lineage, typically composed of small to medium sized blast cells. Most patients with B-ALL present with evidence of bone marrow failure, thrombocytopenia, anemia and neutropenia. Leukocyte number is decreased, lymphadenopathy, hepatomegaly and splenomegaly are frequent. Patients with B-LBL without leukemia are usually asymptomatic and most have limited stage disease. This is primarily a disease of children under 6 years of age
Abstractor Notes
(This code is effective for cases diagnosed 2010 and later. For cases diagnosed prior to 2010 see codes: 9728/3 [lymphomas] or 9836/3 [leukemia].) Occurs mostly in children under six years of age. By definition, bone marrow is involved in all cases classified as B-ALL and peripheral blood is usually involved. Extramedullary involvement is frequent, with more common sites including the central nervous sytem, lymph nodes, spleen, liver and testis in males. The most frequent sites of involvement in B-LBL are the skin, soft tissue, bone and lymph nodes. Cytochemistry seldom contributes to the diagnosis of ALL.
Definitive Diagnostic Methods
Bone marrow
Immunophenotyping
Genetics Data
Clonal DJ rearrangements of the IGH@ gene
T-Cell receptor rearrangements
Immunophenotyping
CD10+
CD19+
CD22+
CD24+
CD79a+
PAX5+
TdT+
Treatments
Chemotherapy
Radiation
Stem cell transplant
Transformations to
No Transformations
Transformations from
No Transformations
Corresponding ICD-9 Codes
204.8 Other lymphoid leukemia
Corresponding ICD-10 Codes
C91.7 Other lymphoid leukemia
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C91.Z Other lymphoid leukemia
Signs and Symptoms
None
Diagnostic Exams
None
Recurrence and Metastases
None
Epidemiology and Mortality
None