B lymphoblastic leukemia/lymphoma with hyperdiploidy

Name
ICD-O-3 Morphology
9815/3
Effective 2010 and later
Reportable
for cases diagnosed 2010 and later
Primary Site(s)
See Module 4: Rules PH7, PH8
Usually presents as a leukemia. Lymphomatous presentation is rare.

Help me code for diagnosis year :

Grade
6 - B-cell
Module Rule
Module 4: PH7, PH8
Alternate Names
ALL with favorable trisomies
High hyperdiploid ALL
Hyperdiploid ALL
Definition
A neoplasm of lymphoblasts committed to the B lineage whose blasts contain >50 and usually <66 chromosomes, typically without translocations or other structural alterations. This leukemia is common in children, accounting for about 25% of cases of B-ALL.
Abstractor Notes
(This code is effective for cases diagnosed 2010 and later. For cases diagnosed prior to 2010 see codes: 9728/3 [lymphoma] or 9836/3 [leukemia].)

The presenting features are generally similar to those of other patients with ALL. Cases of T-ALL should not be included in this code even though those patients have near tetraploid karyotypes.

Immunophenotyping will confirm that the patient has a B-lymphoblastic B-ALL; the genetic testing provides the information needed to classify this neoplasm as a B lymphoblastic leukemia/lymphoma with hyperdiploidy.
Definitive Diagnostic Methods
Bone marrow biopsy
FISH
Genetic testing
Immunophenotyping
Karyotyping
Genetics Data
Extra copies of chromosomes 21, X, 14 and 4
Immunophenotyping
CD10+
CD19+
CD34+
CD45 absent
Treatments
Chemotherapy
Stem cell transplant
Transformations to
There are no known transformations
Transformations from
There are no known transformations
Corresponding ICD-9 Codes
204.8 Other lymphoid leukemia
Corresponding ICD-10 Codes
C91.7 Other lymphoid leukemia
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C91.Z Other lymphoid leukemia
Signs and Symptoms
Anemia
Arthralgias
Bone pain
Hepatomegaly
Lymphoadenopathy
Splenomegaly
Diagnostic Exams
Complete blood count (CBC)
CT (CAT) scan
Cytogenetic analysis
Laparoscopy (rarely performed)
Laparotomy (rarely performed)
MRI (magnetic resonance imaging)
PET (positron emission tomography) scan
Recurrence and Metastases
None
Epidemiology and Mortality
Age: most common in children (not seen in infants, rare in adulthood)
Incidence: 25% of cases of B-ALL
Survival: favorable prognosis, >90% cure of children