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A neoplasm of lymphoblasts committed to the B lineage in which the blasts harbor a translocation between the IL3 gene and the IGH@ gene, resulting in a variable eosinophilia. This diagnosis may be made based on immunophenotypic and genetic findings even if the bone marrow blast count is low.
(This code is effective for cases diagnosed 2010 and later. For cases diagnosed prior to 2010 see codes: 9728/3 [lymphomas] or 9836/3 [leukemia].) A major indicator of this disease is the presence of eosoniphilia. This is a rare neoplasm representing less than 1% of ALL. This neoplasm presents in both children and adults.
Definitive Diagnostic Methods
Bone marrow biopsy
Functional rearrangememt between the IL3 gene on chromosome 5 and the IGH@ gene on chromosome 14