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A neoplasm of lymphoblasts committed to the B lineage whose blasts contain <46 chromosomes. A stricter definition of <45 chromosomes, and possibly even <44 chromosomes more accurately reflects the clinical pathologic entity. This disease is seen in both children and adults, although near haploid ALL (23-29 chromosomes) appears limited to childhood.
(This code is effective for cases diagnosed 2010 and later. For cases diagnosed prior to 2010 see codes: 9728/3 [lymphomas] or 9836/3 [leukemia].) This neoplasm is seen in both children and adults. Patients present with symptoms similar to other patients with ALL. Hypodiploid ALL has a poor prognosis. The prognosis for this disease depends on the number of chromosomes; those with 44-45 chromosomes have the best prognosis. Patients may fare poorly even if they do not have residual disease following therapy.