SEER is an authoritative source of information on cancer incidence and survival in the United States. SEER currently collects and publishes cancer incidence and survival data from population-based cancer registries covering approximately 28 percent of the U.S. population.
Lymphoma derived from subset of naive pre-germinal center cells, localized in primary follicles or in mantle region of secondary follicles; majority of cases displaying unmutated immunoglobulin heavy chain locus. Characterized by atypical small to medium-sized cells in nodular, diffuse, or mantle zone growth pattern.
An agressive type of B-cell non-Hodgkin lymphoma that usually occurs in middle-aged or older adults. It is marked by small to medium sized cancer cells that may be in the lymph nodes, spleen, bone marrow, and GI system.
Mantle cell lymphoma is a B-cell neoplasm generally composed of monomorphic small to medium-sized lymphoid cells with irregular nuclear contours and a CCND1 translocation.
Typical patients are men. At diagnosis, the typical patient is in their 60s and usually presents with advanced disease. About half will have some combination of B symptoms. Swelling of lymph nodes and spleen are usually present. Bone marrow, liver and GI tract involvement occurs in a very high percentage.
Definitive Diagnostic Methods
Heavy and light chain genes rearranged, t(11;14)(q13;q32) in virtually all cases, overexpression CYCLIN D mRNA, mutation or deletions of ATM gene