SEER is an authoritative source of information on cancer incidence and survival in the United States. SEER currently collects and publishes cancer incidence and survival data from population-based cancer registries covering approximately 28 percent of the U.S. population.
Mantle cell lymphoma is a B-cell neoplasm generally composed of monomorphic small to medium-sized lymphoid cells with irregular nuclear contours and a CCND1 translocation.
Lymphomas has subset of naive pre-germinal center cells, localized in primary follicles or in mantle region of secondary follicles. Majority of cases display unmutated immunoglobulin heavy chain locus.
Morphologic variants of mantle cell lymphoma: 1. Blastoid 2. Pleomorphic 3. Small cell 4. Marginal zone-like
Peripheral blood involvement common, present in almost all patients by flow cytometry. B symptoms in about half of patients.
Most patients present in Stage III or IV. Spleen, bone marrow and liver are common metastatic sites.
Patients presenting with peripheral blood, bone marrow and possibly splenic involvement but without adenopathy are reported to have better prognosis.
Definitive Diagnostic Methods
Heavy and light chain genes rearranged, t(11;14)(q13;q32) in virtually all cases, overexpression CYCLIN D mRNA, mutation or deletions of ATM gene