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Cutaneous involvement consists of perivascular or more diffuse dermal infiltrations without epidermotropism.
The spleen histology shows dense red pulp infiltration which invades the spleen capsule, blood vessels and atrophied white pulp.
There is diffuse lymph node involvement and tends to predominate in the paracortical areas, sometimes with sparing of follicles. Prominent high-endothelial venules may be numerous and are often infiltrated by neoplastic cells.
Definitive Diagnostic Methods
Bone marrow biopsy
Peripheral blood smear
Inversion chromosome 14 with breakpoints in the long arm at q11 and q32