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Code grade specified by pathologist. If no grade specified, code 9
M3 Module 5: PH10
Acute myeloblastic leukemia without maturation
Acute myeloid leukemia, M1
AML without maturation
Characterized by a high percentage of bone marrow blasts without significant evidence of maturation to more mature neutrophils. Blasts constitute 90% or more of the non-erythroid cells. The myeloid nature of the blasts is demonstrated by MPO or SBB (>3% of blasts) positivity and/or Auer rods.
Patients usually present with evidence of BM failure with anemia, thrombocytopenia and neutropenia. This neoplasm may occur at any age but the majority of patients are adults. The provisional diagnoses during workup may include AML without maturation, AML with maturation and ALL.