Acute myeloid leukemia without maturation

Name
Acute myeloid leukemia without maturation
ICD-O-3 Morphology
9873/3
Effective 2001 and later
Reportable
for cases diagnosed 2001 and later
Primary Site(s)
C421
Primary site must be bone marrow (C421)

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Grade
Code grade specified by pathologist. If no grade specified, code 9
Module Rule
See abstractor notes
Alternate Names
Acute myeloblastic leukemia without maturation
Acute myeloid leukemia, M1
AML without maturation
FAB M1
Definition
Characterized by a high percentage of bone marrow blasts without significant evidence of maturation to more mature neutrophils. Blasts constitute 90% or more of the non-erythroid cells. The myeloid nature of the blasts is demonstrated by MPO or SBB (>3% of blasts) positivity and/or Auer rods.
Abstractor Notes
The provisional diagnoses during workup may include
1. AML without maturation
2. AML with maturation
3. Acute lymphoblastic leukemia (ALL)

If the leukemia occurs before or simultaneously with Myeloid Sarcoma (9930/3), see M3 and Module 5:PH10
Definitive Diagnostic Methods
Bone marrow biopsy
Immunophenotyping
Genetics Data
None
Immunophenotyping
CD3-
CD13+
CD22-
CD33+
CD34+ (in approx. 70% of cases)
CD79a-
CD117+
HLA-DR+ (in approx. 70% of cases)
Treatments
Chemotherapy
Transformations to
None
Corresponding ICD-9 Codes
205.0 Acute myeloid leukemia
Corresponding ICD-10 Codes
C92.0 Acute myeloid leukemia
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C92.0 Acute myeloblastic leukemia
Signs and Symptoms
Anemia
Bone marrow failure
Easy bruising or bleeding
Fatigue
Fever
Petechiae
Shortness of breath
Weakness
Weight loss or loss of appetite
Diagnostic Exams
Bone marrow aspiration and biopsy
Complete blood count (CBC)
CT (CAT) scan
Reverse transcription-polymerase chain reaction test (RT-PCR)
Progression and Transformation
None
Epidemiology and Mortality
Age: 46 years median age
Incidence: 5-10% of all AML cases