Acute myeloid leukemia without maturation

Name
Acute myeloid leukemia without maturation
ICD-O-3 Morphology
9873/3
Effective 2001 and later
Reportable
for cases diagnosed 2001 and later
Primary Site(s)
C421

Help me code for dx year :

Grade
Code grade specified by pathologist. If no grade specified, code 9
Module Rule
M3 Module 5: PH10
Alternate Names
Acute myeloblastic leukemia without maturation
Acute myeloid leukemia, M1
AML without maturation
FAB M1
Definition
Characterized by a high percentage of bone marrow blasts without significant evidence of maturation to more mature neutrophils. Blasts constitute 90% or more of the non-erythroid cells. The myeloid nature of the blasts is demonstrated by MPO or SBB (>3% of blasts) positivity and/or Auer rods.
Abstractor Notes
Patients usually present with evidence of BM failure with anemia, thrombocytopenia and neutropenia. This neoplasm may occur at any age but the majority of patients are adults. The provisional diagnoses during workup may include AML without maturation, AML with maturation and ALL.
Definitive Diagnostic Methods
Bone marrow biopsy
Immunophenotyping
Genetics Data
No specific chromosomal abnormality
Immunophenotyping
CD3-
CD13+
CD22-
CD33+
CD34+ (in approx. 70% of cases)
CD79a-
CD117+
HLA-DR+ (in approx. 70% of cases)
Treatments
Chemotherapy
Transformations to
None
Corresponding ICD-9 Codes
205.0 Acute myeloid leukemia
Corresponding ICD-10 Codes
C92.0 Acute myeloid leukemia
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C92.0 Acute myeloblastic leukemia
Signs and Symptoms
None
Diagnostic Exams
None
Recurrence and Metastases
None
Epidemiology and Mortality
None