Acute monoblastic and monocytic leukemia

Name
Acute monoblastic and monocytic leukemia
ICD-O-1 Morphology
9891/3
Effective 1978 - 1991
ICD-O-2 Morphology
9891/3
Effective 1992 - 2000
ICD-O-3 Morphology
9891/3
Effective 2001 and later
Reportable
for cases diagnosed 1978 and later
Primary Site(s)
C421
Primary site must be bone marrow (C421)

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Grade
Code grade specified by pathologist. If no grade specified, code 9
Module Rule
None
Alternate Names
Acute monoblastic leukemia
Acute monoblastic leukemia and acute monocytic leukemia
Acute monoblastic leukemia, M5a
Acute monocytic leukemia
Acute monocytic leukemia, M5b
FAB M5 (includes all variants)
Monoblastic leukemia, NOS
Definition
AML in which 80% or more of the leukemic cells are of monocytic lineage including monoblasts, promonocytes and monocytes; a minor neutrophil component, less than 20%, may be present. In acute monoblastic leukemia (FAB M5a), the majority of the monocytic cells are monoblasts. In acute monocytic leukemia (FAB M5b), the majority are promonocytes.
Abstractor Notes
This neoplasm is one of the myeloid leukemias in which 80% or more of the leukemic cells are of monocytic lineage. Myeloid associated non-specific cytogenetic abnormalities are present in the majority of cases but do not provide a definitive diagnosis.

If the leukemia occurs before or simultaneously with Myeloid Sarcoma (9930/3), see M3 and Module 5: PH10.
Definitive Diagnostic Methods
Bone marrow biopsy
Flow cytometry
Genetic testing
Histologic confirmation
Immunophenotyping
Genetics Data
Deletions and translocations involving chromosome 11 and q23
Immunophenotyping
CD4+
CD11b+
CD11c+
CD13+
CD14+
CD15+
CD33+
CD36+
CD64+
CD65+
CD68+
HLA-DR+
Lysozyme+
Treatments
Chemotherapy
Stem cell transplant
Transformations to
There are no known transformations
Transformations from
There are no known transformations
Corresponding ICD-9 Codes
206.0 Acute monocytic leukemia
Corresponding ICD-10 Codes
C93.0 Acute monocytic leukemia
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C93.0 Acute monoblastic/monocytic leukemia
Signs and Symptoms
Bleeding disorders
Central nervous involvement common
Cutaneous and gingival infiltration
Easy bruising and bleeding
Shortness of breath
Weakness
Weight loss or loss of appetite
Diagnostic Exams
Progression and Transformation
None
Epidemiology and Mortality
Age (acute monoblastic leukemia): most common in young
Age (acute monocytic leukemia): 49 years median age
Incidence: <5% of all cases of AML
Sex: female predominance