Acute monoblastic and monocytic leukemia

Name
Acute monoblastic and monocytic leukemia
ICD-O-1 Morphology
9891/3
Effective 1978 - 1991
ICD-O-2 Morphology
9891/3
Effective 1992 - 2000
ICD-O-3 Morphology
9891/3
Effective 2001 and later
Reportable
for cases diagnosed 1978 and later
Primary Site(s)
C421

Help me code for diagnosis year :

Grade
Code grade specified by pathologist. If no grade specified, code 9
Module Rule
M3 Module 5: PH10
Alternate Names
Acute monoblastic leukemia
Acute monoblastic leukemia and acute monocytic leukemia
Acute monoblastic leukemia, M5a
Acute monocytic leukemia
Acute monocytic leukemia, M5b
FAB M5 (includes all variants)
Monoblastic leukemia, NOS
Definition
AML in which 80% or more of the leukemic cells are of monocytic lineage including monoblasts, promonocytes and monocytes; a minor neutrophil component, less than 20%, may be present. In acute monoblastic leukemia (FAB M5a), the majority of the monocytic cells are monoblasts. In acute monocytic leukemia (FAB M5b), the majority are promonocytes.
Abstractor Notes
Patients commonly present with bleeding disorders. Extramedullary masses, cutaneous and gingival infiltration and central nervous system involvement are common. This neoplasm is one of the myeloid leukemias in which 80% or more of the leukemic cells are of monocytic lineage. Myeloid associated non-specific cytogenetic abnormalities are present in the majority of cases but do not provide a definitive diagnosis.
Definitive Diagnostic Methods
Bone marrow
Flow cytometry
Genetic testing
Histologic confirmation
Genetics Data
Deletions and translocations involving chromosome 11 and q23
Immunophenotyping
CD4+
CD11b+
CD11c+
CD13+
CD14+
CD15+
CD33+
CD36+
CD64+
CD65+
CD68+
HLA-DR+
Lysozyme+
Treatments
Chemotherapy
Stem cell transplant
Transformations to
No Transformations
Transformations from
No Transformations
Corresponding ICD-9 Codes
206.0 Acute monocytic leukemia
Corresponding ICD-10 Codes
C93.0 Acute monocytic leukemia
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C93.0 Acute monoblastic/monocytic leukemia
Signs and Symptoms
None
Diagnostic Exams
None
Recurrence and Metastases
None
Epidemiology and Mortality
None