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Code grade specified by pathologist. If no grade specified, code 9
M3 Module 5: PH10
Acute monoblastic leukemia
Acute monoblastic leukemia and acute monocytic leukemia
Acute monoblastic leukemia, M5a
Acute monocytic leukemia
Acute monocytic leukemia, M5b
FAB M5 (includes all variants)
Monoblastic leukemia, NOS
AML in which 80% or more of the leukemic cells are of monocytic lineage including monoblasts, promonocytes and monocytes; a minor neutrophil component, less than 20%, may be present. In acute monoblastic leukemia (FAB M5a), the majority of the monocytic cells are monoblasts. In acute monocytic leukemia (FAB M5b), the majority are promonocytes.
Patients commonly present with bleeding disorders. Extramedullary masses, cutaneous and gingival infiltration and central nervous system involvement are common. This neoplasm is one of the myeloid leukemias in which 80% or more of the leukemic cells are of monocytic lineage. Myeloid associated non-specific cytogenetic abnormalities are present in the majority of cases but do not provide a definitive diagnosis.
Definitive Diagnostic Methods
Deletions and translocations involving chromosome 11 and q23