Acute megakaryoblastic leukemia

Name
Acute megakaryoblastic leukemia
ICD-O-1 Morphology
9910/3
Effective 1978 - 1991
ICD-O-2 Morphology
9910/3
Effective 1992 - 2000
ICD-O-3 Morphology
9910/3
Effective 2001 and later
Reportable
for cases diagnosed 1978 and later
Primary Site(s)
C421

Help me code for dx year :

Grade
Code grade specified by pathologist. If no grade specified, code 9
Module Rule
M3 Module 5: PH10
Alternate Names
AMKL
FAB M7
Megakaryocytic leukemia
Definition
An acute leukemia in which =>50% of the blasts are of megakaryocytic lineage.
Abstractor Notes
This is a rare type of pediatric acute myeloblastic leukemia. Approximately 1/3 of cases are associated with t(1;22)(p13;q13) and 1/3 with Down Syndrome. Children may present with a broad variety of atypical symptoms which may range from minor to life-threatening conditions. Most patients present with fatigue and/or asthenia, which is often accompanied by persistent fever. Severe infections may occur due to the diminished neutrophil count and function. Easy brusing may occur as well as bleeding (epistaxis, oral or gingival bleeding, rectal blood loss, menorrhagia, cerebral hemorrhage). The bleeding disorders result from thrombocytopenia.
Definitive Diagnostic Methods
Bone marrow biopsy
Flow cytometry for immunophenotype
Peripheral blood smear
Genetics Data
t(1;22)(p13;q13)
Immunophenotyping
CD36+
CD41 (glycoprotein IIb/IIIa)
CD42 (glycoprotein Ib-less frequently present)
CD61 (glycoprotein IIIa)
Treatments
Chemotherapy
Radiation
Stem cell transplant
Transformations to
No Transformations
Transformations from
No Transformations
Corresponding ICD-9 Codes
207.2 Megakaryocytic leukemia
Corresponding ICD-10 Codes
C94.2 Acute megakaryoblastic leukemia
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C94.2 Acute megakaryoblastic leukemia
Signs and Symptoms
None
Diagnostic Exams
None
Recurrence and Metastases
None
Epidemiology and Mortality
None