Acute megakaryoblastic leukemia

Name
Acute megakaryoblastic leukemia
ICD-O-1 Morphology
9910/3
Effective 1978 - 1991
ICD-O-2 Morphology
9910/3
Effective 1992 - 2000
ICD-O-3 Morphology
9910/3
Effective 2001 and later
Reportable
for cases diagnosed 1978 and later
Primary Site(s)
C421
Primary site must be bone marrow (C421)

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Grade
Code grade specified by pathologist. If no grade specified, code 9
Module Rule
None
Alternate Names
AMKL
FAB M7
Megakaryocytic leukemia
Definition
An acute leukemia in which =>50% of the blasts are of megakaryocytic lineage.
Abstractor Notes
This is a rare type of pediatric acute myeloblastic leukemia. Approximately 1/3 of cases are associated with t(1;22)(p13;q13) and 1/3 with Down Syndrome.

If the leukemia occurs before or simultaneously with Myeloid Sarcoma (9930/3), see M3 and Module 5:PH10
Definitive Diagnostic Methods
Bone marrow biopsy
Genetic testing
Immunophenotyping
Peripheral blood smear
Genetics Data
t(1;22)(p13;q13)
Immunophenotyping
CD36+
CD41 (glycoprotein IIb/IIIa)
CD42 (glycoprotein Ib-less frequently present)
CD61 (glycoprotein IIIa)
Treatments
Chemotherapy
Radiation
Stem cell transplant
Transformations to
There are no known transformations
Transformations from
There are no known transformations
Corresponding ICD-9 Codes
207.2 Megakaryocytic leukemia
Corresponding ICD-10 Codes
C94.2 Acute megakaryoblastic leukemia
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C94.2 Acute megakaryoblastic leukemia
Signs and Symptoms
Easy bruising or bleeding
Severe infections (due to decreased neutrophils)
Thrombocytosis
Progression and Transformation
None
Epidemiology and Mortality
Age: occurs in both children and adults
Incidence: <5% of all AML cases