SEER is an authoritative source of information on cancer incidence and survival in the United States. SEER currently collects and publishes cancer incidence and survival data from population-based cancer registries covering approximately 28 percent of the U.S. population.
An extranodal and systemic neoplasm derived from cytotoxicT-cells usually of Gamma Delta T-cell receptor type, medium in size, demonstrating marked sinusoidal infiltration of spleen, liver and bone marrow. Patients frequently have a history of chronic immunosuppression, including kidney transplantation.
Patients with hepatosplenic T-cell lymphoma present with marked splenomegaly. The spleen is enlarged with diffuse involvement of the red pulp without any gross lesions. Diffuse hepatic enlargement is present as well.
Lymphadenopathy usually not present. Bone marrow frequently involved. Peripheral blood involvement uncommon at presentation but may occur later in clinical course.
Definitive Diagnostic Methods
2-5 copies of i(7)(q10)
Isochromosome 7q present
Numerical and structural aberrations of the second chromosome 7