SEER is an authoritative source of information on cancer incidence and survival in the United States. SEER currently collects and publishes cancer incidence and survival data from population-based cancer registries covering approximately 28 percent of the U.S. population.
Note: 11q23 abnormalities don't always correlate with MLL gene rearrangement
AML with 11q23 abnormalities is usually associated with monocytic features. More common in children. Two subgroups of patients exhibit 11q23: 1) AML in infants and 2) therapy-related leukemia usually occurring after treatment with DNA topoisomerase II inhibitors
Patients may present with DIC and extramedullary monocytic sarcomas and/or tissue infiltration (gingiva, skin).
Translocations involving chromosomeband 11q23 occur frequently in both AML and ALL; at least 30 different partner chromosomes are involved in recurring reciprocal 11q23 translocations, suggesting that the 11q23 breakpoint region may contain genomically unstable sequences that lead to chromosomal recombination events.
The provisional diagnoses may include
2. AML without maturation
3. Acute lymphoblasticleukemia (ALL)
4. AML with maturation.
The patients with ALL have a low percentage of MPO-positive blasts while the AML with maturation has a higher percentage of MPO-positive blasts.
If the leukemia occurs before or simultaneously with Myeloid Sarcoma (9930/3), see M3 and Module 5:PH10.