Myeloid sarcoma

Name
Myeloid sarcoma
ICD-O-1 Morphology
9930/3
Effective 1978 - 1991
ICD-O-2 Morphology
9930/3
Effective 1992 - 2000
ICD-O-3 Morphology
9930/3
Effective 2001 and later
Reportable
for cases diagnosed 1978 and later
Primary Site(s)
See Module 7
Primary site cannot be bone marrow (C421). Most common sites of involvement: skin, lymph nodes, gastrointestinal tract, bone, soft tissue and testis.

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Grade
Code grade specified by pathologist. If no grade specified, code 9
Module Rule
None
Alternate Names
Chloroma
Granulocytic sarcoma
GS
Definition
Tumor mass of myeloblasts or immature myeloid cells occurring in a site other than bone marrow.

This is a solid tumor composed of immature malignant white blood cells called myeloblasts.

A chloroma is an extramedullary manifestation of acute myeloid leukemia; in other words, it is a solid collection of leukemic cells occurring outside of the bone marrow.
Abstractor Notes
Myeloid sarcoma may occur de novo; it may precede or coincide with AML, or represent acute blastic transformation of myelodysplastic syndromes. Myeloid sarcoma may also be the initial manifestation of relapse in a patient with previously diagnosed AML

If Myeloid Sarcoma occurs simultaneously or after an acute myeloid leukemia, see M3 and Module 5:PH10.
Definitive Diagnostic Methods
Genetic testing
Histologic confirmation
Immunophenotyping
Genetics Data
5q-
16q-
20q-
Inv(16)
MLL-rearrangement
Monosomy 7
Monosomy 16
Trisomy 4
Trisomy 8
Trisomy 11
Immunophenotyping
CD68/KP1
Treatments
Chemotherapy
Radiation
Transformations to
None
Transformations from
Corresponding ICD-9 Codes
205.3 Myeloid sarcoma
Corresponding ICD-10 Codes
C92.3 Myeloid sarcoma
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C92.3 Myeloid sarcoma
Signs and Symptoms
Easy bruising or bleeding
Fatigue
Fever
Petechiae
Shortness of breath
Weakness
Weight loss or loss of appetite
Diagnostic Exams
Bone marrow aspiration and biopsy
Complete blood count (CBC)
CT (CAT) scan
Reverse transcription-polymerase chain reaction test (RT-PCR)
Progression and Transformation
None
Epidemiology and Mortality
Age: 56 years median (1 month to 89 years range)
Sex: male predominance
Survival: higher probability or prolonged survival for patients who have allogeneic or autologous BM transplantation