Acute myeloid leukemia with maturation

Name
Acute myeloid leukemia with maturation
ICD-O-3 Morphology
9874/3
Effective 2001 and later
Reportable
for cases diagnosed 2001 and later
Primary Site(s)
C421
Primary site must be bone marrow (C421)

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Grade
Code grade specified by pathologist. If no grade specified, code 9
Module Rule
See abstractor notes
Alternate Names
Acute myeloid leukemia, M2
AML with maturation
FAB M2, NOS
Definition
Characterized by the presence of >20% blasts in the bone marrow or peripheral blood. There is evidence of maturation (>=10% maturing cells of neutrophil lineage); cells of monocyte lineage compromise <20% of BM cells.
Abstractor Notes
The provisional diagnosis during workup may include RA with excess blasts, AML without maturation, AML with maturation, and acute myelomonocytic leukemia.

The immunophenotyping information listed below is useful only because it shows those factors that are positive for all myeloid leukemias. The bone marrow only identifies a myeloid neoplasm. Neither the bone marrow biopsy nor the immunophenotyping provide a definitive diagnosis of AML with maturation.

If the leukemia occurs before or simultaneously with Myeloid Sarcoma (9930/3), see M3 and Module 5:PH10.
Definitive Diagnostic Methods
Clinical diagnosis
Immunophenotyping
Genetics Data
None
Immunophenotyping
CD11b
CD13
CD15
CD33
CD65
Treatments
Chemotherapy
Stem cell transplant
Transformations to
None
Corresponding ICD-9 Codes
205.0 Acute myeloid leukemia
Corresponding ICD-10 Codes
C92.0 Acute myeloid leukemia
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C92.0 Acute myeloblastic leukemia
Signs and Symptoms
Easy bruising or bleeding
Shortness of breath
Variable white blood count
Weakness
Weight loss or loss of appetite
Progression and Transformation
None
Epidemiology and Mortality
Age: all age groups with 20% less than 25 years and 40% greater than 60
Incidence: 10% of all AML cases