Mixed cellularity classical Hodgkin lymphoma

Name
Mixed cellularity classical Hodgkin lymphoma
ICD-O-1 Morphology
9652/3
Effective 1978 - 1991
ICD-O-2 Morphology
9652/3
Effective 1992 - 2000
ICD-O-3 Morphology
9652/3
Effective 2001 and later
Reportable
for cases diagnosed 1978 and later
Primary Site(s)
C770-C779

Help me code for dx year :

Grade
Code grade specified by pathologist. If no grade specified, code 9
Module Rule
None
Alternate Names
Classical Hodgkin lymphoma, mixed cellularity, NOS
Hodgkin lymphoma, mixed cellularity, NOS
MCCHL
MC-HL
Definition
Subtype of classic Hodgkin's lymphoma (HL), classic Reed-Sternberg (RS) cells with prominent inclusion-like nucleoli, lacunar cells inconspicuous, nodular fibrosing sclerosis absent. Usually associated with diffuse architectural effacement. Rich inflammatory background with numerous eosinophils, plasma cells, histiocytes.
Abstractor Notes
Mixed cellularity classical Hodgkin lymphoma (MCCHL) frequently involves peripheral lymph nodes. Mediastinal involvement is uncommon. The spleen is involved in 30%, bone marrow in 10%, liver in 3%, and other organs in 1-3%. MCCHL is more frequent in patients with HIV infection and in developing countries. The median age is 38 years and approximately 70% are male. With current regimens MCCHL has approximately the same prognosis as nodular sclerosis and a better prognosis than lymphocyte-depleted CHL.

Preferred primary sites are listed for this disease in the primary site field; however, involvement in other sites is possible, but rare. If you have confirmation that the only involved site is something other than the preferred primary listed, then code to that primary site.
Definitive Diagnostic Methods
Histologic confirmation
Immunophenotype
Genetics Data
None
Immunophenotyping
CD15+
CD30+
CD45-
EB-encoded LMP1
EBER+
Treatments
Chemotherapy
Hormone
Radiation
Transformations to
No Transformations
Corresponding ICD-9 Codes
201.6 Hodgkin's disease, mixed cellularity
Corresponding ICD-10 Codes
C81.2 Hodgkin's disease, mixed cellularity
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C81.2 Mixed cellularity classical Hodgkin lymphoma
Signs and Symptoms
None
Diagnostic Exams
None
Recurrence and Metastases
None
Epidemiology and Mortality
None