SEER is an authoritative source of information on cancer incidence and survival in the United States. SEER currently collects and publishes cancer incidence and survival data from population-based cancer registries covering approximately 28 percent of the U.S. population.
Lymph nodes (C770-C779) are the usual primary sites; however, involvement in other sites is possible. If you have confirmation that the only involved site is something other than the lymph nodes, then code to that primary site. See Module 7.
Subtype of classic Hodgkin's lymphoma (HL), classic Reed-Sternberg (RS) cells with prominent inclusion-like nucleoli, lacunar cells inconspicuous, nodular fibrosing sclerosis absent. Usually associated with diffuse architectural effacement. Rich inflammatory background with numerous eosinophils, plasma cells, histiocytes.
Mixed cellularity classical Hodgkin lymphoma (MCCHL) frequently involves peripheral lymph nodes. Mediastinal involvement is uncommon. The spleen is involved in 30%, bone marrow in 10%, liver in 3%, and other organs in 1-3%. MCCHL is more frequent in patients with HIV infection and in developing countries.
With current regimens, MCCHL has approximately the same prognosis as nodular sclerosis and a better prognosis than lymphocyte-depleted CHL.
Per WHO, Hodgkin lymphomas are primarily B-cell lymphomas. If the medical record states B-cell, code 6. Since there are Hodgkin lymphomas that are not B-cell, the default grade is 9 (unknown) where the documentation does not specifically state B-cell.