SEER is an authoritative source of information on cancer incidence and survival in the United States. SEER currently collects and publishes cancer incidence and survival data from population-based cancer registries covering approximately 28 percent of the U.S. population.
Most common subtype of Hodgkin lymphoma. Nodular growth pattern, broad bands of fibrosis, characteristic variant of Reed Sternberg cell. Lacunar cell-abundant clear cytoplasm, sharply demarcated cell membrane; mononuclear, hyperlobated, or multinucleated; smaller nucleoli than in classic RS cells.
Nodular sclerosis classical Hodgkin lymphoma is a subtype of CHL characterized by collagen bands that surround at least one nodule, and Hodgkin and Reed-Sternberg cells with lacunar type morphology.
Nodular sclerosis classical Hodgkin lymphoma (NSCHL) occurs in the mediastinum in 89% of the cases, bulky disease in 54%, splenic and/or lung involvement in 8-10%, bone involvement in 5%, bone marrow involvement in 3%, and liver involvement in 2%. Most patients present with stage II disease. B symptoms are encountered in approximately 40% of cases. NSCHL has a better prognosis than that of other types of CHL. Massive medistinal disease is an adverse prognostic factor.
This is the most common subtype of HL in developed countries. It usually affects females more than males and has a median age of onset at approximately 28 years.
Hodgkin lymphoma, nodular sclerosis, cellular phase 9664/3 is obsolete. Those cases are now coded to this classification, 9663/3.
Preferred primary sites are listed for this disease in the primary site field; however, involvement in other sites is possible, but rare. If you have confirmation that the only involved site is something other than the preferred primary listed, then code to that primary site.