Nodular sclerosis classical Hodgkin lymphoma

Name
Nodular sclerosis classical Hodgkin lymphoma
ICD-O-1 Morphology
9656/3
Effective 1978 - 1991
ICD-O-2 Morphology
9663/3
Effective 1992 - 2000
ICD-O-3 Morphology
9663/3
Effective 2001 and later
Reportable
for cases diagnosed 1978 and later
Primary Site(s)
C770-C779
Lymph nodes (C770-C779) are the usual primary sites; however, involvement in other sites is possible. If you have confirmation that the only involved site is something other than the lymph nodes, then code to that primary site. See Module 7.

Help me code for diagnosis year :

Grade
Code grade specified by pathologist. If no grade specified, code 9
Module Rule
None
Alternate Names
Classical Hodgkin lymphoma, nodular sclerosis, cellular phase
Classical Hodgkin lymphoma, nodular sclerosis, grade 1
Classical Hodgkin lymphoma, nodular sclerosis, grade 2
Classical Hodgkin lymphoma, nodular sclerosis, NOS
Classical Hodgkin lymphoma, nodular sclerosis, syncytial variant
Hodgkin disease, nodular sclerosis, lymphocyte predominance
Hodgkin disease, nodular sclerosis, lymphocyte depletion
Hodgkin disease, nodular sclerosis, mixed cellularity
Hodgkin disease, nodular sclerosis, NOS
Hodgkin lymphoma, nodular sclerosis, grade 1
Hodgkin lymphoma, nodular sclerosis, grade 2
Hodgkin lymphoma, nodular sclerosis, NOS
Nodular sclerosis Hodgkin lymphoma
NS-HL
NSCHL
Definition
Most common subtype of Hodgkin lymphoma. Nodular growth pattern, broad bands of fibrosis, characteristic variant of Reed Sternberg cell. Lacunar cell-abundant clear cytoplasm, sharply demarcated cell membrane; mononuclear, hyperlobated, or multinucleated; smaller nucleoli than in classic RS cells.

Nodular sclerosis classical Hodgkin lymphoma is a subtype of CHL characterized by collagen bands that surround at least one nodule, and Hodgkin and Reed-Sternberg cells with lacunar type morphology.
Abstractor Notes
Nodular sclerosis classical Hodgkin lymphoma (NSCHL) occurs in the mediastinum in 90% of the cases, bulky disease in 54%, splenic and/or lung involvement in 8-10%, bone involvement in 5%, bone marrow involvement in 3%, and liver involvement in 2%.

Most patients present with stage II disease. B symptoms are encountered in approximately 40% of cases. Massive mediastinal disease is an adverse prognostic disease.
Definitive Diagnostic Methods
Histologic confirmation
Immunophenotyping
Genetics Data
None
Immunophenotyping
CD15+
CD30+
CD45-
Treatments
Chemotherapy
Hormone
Radiation
Transformations to
None
Corresponding ICD-9 Codes
201.5 Hodgkin's disease, nodular sclerosis
Corresponding ICD-10 Codes
C81.1 Hodgkin's disease, nodular sclerosis
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C81.1 Nodular sclerosis classical Hodgkin lymphoma
Signs and Symptoms
Drenching night sweats
Fatigue
Fever (for no known reason)
Mediastinal mass (bulky disease)
Pain in the chest, abdomen, bones (for no known reason)
Painless swelling in the lymph nodes
Skin rash or itchy skin
Weight loss (for no known reason)
Diagnostic Exams
CT (CAT) scan
MRI (magnetic resonance imaging)
PET (positron emission tomography) scan
Physican exam and history (H&P)
Recurrence and Metastases
None
Epidemiology and Mortality
Age: peaks at 15-34 years
Incidence: 70% of classical Hodgkin lymphomas, most common subtype of Hodgkin lymphoma in developed countries
Sex: no male or female predominance
Survival: better survival than other types of CHL