Lymphocyte-depleted classical Hodgkin lymphoma

Name
Lymphocyte-depleted classical Hodgkin lymphoma
ICD-O-1 Morphology
9653/3
Effective 1978 - 1991
ICD-O-2 Morphology
9653/3
Effective 1992 - 2000
ICD-O-3 Morphology
9653/3
Effective 2001 and later
Reportable
for cases diagnosed 1978 and later
Primary Site(s)
C770-C779

Help me code for diagnosis year :

Grade
Code grade specified by pathologist. If no grade specified, code 9
Module Rule
None
Alternate Names
Classical Hodgkin lymphoma, lymphocyte depletion, NOS
Hodgkin lymphoma, lymphocyte depletion, NOS
LD-HL
LDCHL
Definition
Most uncommon subtype of Hodgkin lymphoma, less than 5% of cases. Variable morphology, consistent relative predominance of Reed-Sternberg cells and variants with depletion of non-neoplastic lymphocytes. Fibrotic and reticular/sarcomatous subtypes.
Abstractor Notes
Lymphocyte-depleted classical Hodgkin lymphoma (LDCHL) has a predilection for retroperitoneal lymph nodes, abdominal organs, and bone marrow. Compared to other subtypes of CHL, LDCHL presents at a more advanced stage (III-IV) and with B symptoms. Prior to modern therapy the course of LDCHL was aggressive and it has remained so in some parts of Europe.

Preferred primary sites are listed for this disease in the primary site field; however, involvement in other sites is possible, but rare. If you have confirmation that the only involved site is something other than the preferred primary listed, then code to that primary site.
Definitive Diagnostic Methods
Histologic confirmation
Immunophenotyping
Genetics Data
None
Immunophenotyping
CD15+
CD30+
CD45-
EBV positive cases stain positively for LMP
Treatments
Chemotherapy
Hormone
Radiation
Corresponding ICD-9 Codes
201.7 Hodgkin's disease, lymphocytic depletion
Corresponding ICD-10 Codes
C81.3 Hodgkin's disease, lymphocytic depletion
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C81.3 Lymphocyte depleted classical Hodgkin lymphoma
Signs and Symptoms
None
Diagnostic Exams
None
Recurrence and Metastases
None
Epidemiology and Mortality
None