SEER is an authoritative source of information on cancer incidence and survival in the United States. SEER currently collects and publishes cancer incidence and survival data from population-based cancer registries covering approximately 28 percent of the U.S. population.
Code grade specified by pathologist. If no grade specified, code 9
Classical Hodgkin lymphoma, lymphocyte depletion, NOS
Hodgkin lymphoma, lymphocyte depletion, NOS
Most uncommon subtype of Hodgkin lymphoma, less than 5% of cases. Variable morphology, consistent relative predominance of Reed-Sternberg cells and variants with depletion of non-neoplastic lymphocytes. Fibrotic and reticular/sarcomatous subtypes.
Lymphocyte-depleted classical Hodgkin lymphoma (LDCHL) has a predilection for retroperitoneal lymph nodes, abdominal organs, and bone marrow. Compared to other subtypes of CHL, LDCHL presents at a more advanced stage (III-IV) and with B symptoms. Prior to modern therapy the course of LDCHL was aggressive and it has remained so in some parts of Europe.
Preferred primary sites are listed for this disease in the primary site field; however, involvement in other sites is possible, but rare. If you have confirmation that the only involved site is something other than the preferred primary listed, then code to that primary site.