Lymphocyte-depleted classical Hodgkin lymphoma

Name
Lymphocyte-depleted classical Hodgkin lymphoma
ICD-O-1 Morphology
9653/3
Effective 1978 - 1991
ICD-O-2 Morphology
9653/3
Effective 1992 - 2000
ICD-O-3 Morphology
9653/3
Effective 2001 and later
Reportable
for cases diagnosed 1978 and later
Primary Site(s)
C770-C779
See Module 7. Lymph nodes (C770-C779) are the usual primary sites; however, involvement in other sites is possible. If you have confirmation that the only involved site is something other than lymph nodes, then code to that primary site.

Help me code for diagnosis year :

Grade
Code grade specified by pathologist. If no grade specified, code 9
Module Rule
None
Alternate Names
Classical Hodgkin lymphoma, lymphocyte depletion, NOS
Hodgkin lymphoma, lymphocyte depletion, NOS
LD-HL
LDCHL
Definition
Most uncommon subtype of Hodgkin lymphoma. Variable morphology, consistent relative predominance of Reed-Sternberg cells and variants with depletion of non-neoplastic lymphocytes. Fibrotic and reticular/sarcomatous subtypes.
Abstractor Notes
Lymphocyte-depleted classical Hodgkin lymphoma (LDCHL) has a predilection for retroperitoneal lymph nodes, abdominal organs, and bone marrow. Compared to other subtypes of CHL, LDCHL presents at a more advanced stage (III-IV) and with B symptoms.

Prior to modern therapy the course of LDCHL was aggressive and it has remained so in some parts of Europe and developing countries.

Per WHO, Hodgkin lymphomas are primarily B-cell lymphomas. If the medical record states B-cell, code 6. Since there are Hodgkin lymphomas that are not B-cell, the default grade is 9 (unknown) where the documentation does not specifically state B-cell.
Definitive Diagnostic Methods
Histologic confirmation
Immunophenotyping
Genetics Data
None
Immunophenotyping
CD15+
CD30+
CD45-
EBV positive cases stain positively for LMP
Treatments
Chemotherapy
Hormone
Radiation
Transformations to
Transformation to DLBCL is rare
Corresponding ICD-9 Codes
201.7 Hodgkin's disease, lymphocytic depletion
Corresponding ICD-10 Codes
C81.3 Hodgkin's disease, lymphocytic depletion
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C81.3 Lymphocyte depleted classical Hodgkin lymphoma
Signs and Symptoms
Drenching night sweats
Fatigue
Fever (for no known reason)
Pain in the chest, abdomen, or bones (for no known reason)
Painless swelling in the lymph nodes
Retroperitoneal lymphadenopathy
Skin rash or itchy skin
Weight loss (for no known reason)
Diagnostic Exams
CT (CAT) scan
Complete blood count (CBC)
MRI (magnetic resonance imaging)
PET (positron emission tomography) scan
Recurrence and Metastases
None
Epidemiology and Mortality
Age: 30-37 years median age
Incidence: <1% of classical Hodgkin lymphomas
Sex: male predominance
Survival: good prognosis