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Neoplasm of small B lymphocytes, plasmacytoid lymphocytes, and plasma cells, usually involving bone marrow, lymph nodes, spleen; usually lacking CD5; serum monoclonal protein of IgM in most cases with consequent hyperviscosity symptoms.
Most cases of lympholasmacytic lymphoma (LPL) involve the bone marrow; some cases have involvement of lymph nodes and/or organs. Peripheral blood may be involved.
LPL is an NOS; both Waldenstrom macroglobulinemia and Gamma heavy chain disease are variants of LPL. All three diseases are diagnosed by an increased number of immunoglobulins. WM is caused by increased lymphocytes which causes an increase in IgM. Gamma heavy chain disease is caused by increased plasma cells which results in an increase of IgG. LPL has mixed abnormalities, both the lymphocytes and plasma cells are increased which results in an abnormally high IgM AND IgG.
Waldenstrom Macroglobulinemia (WM) is a subset of LPL; WM has its own code (9761/3). See the abstractor notes for WM for more information.
Gamma heavy chain disease (9762/3) is a variant of LPL, since it has it's own code, use the specific code 9767/3. See the abstractor notes for Gamma heavy chain disease for more information.