Lymphoplasmacytic lymphoma

Name
Lymphoplasmacytic lymphoma
ICD-O-1 Morphology
9611/3
Effective 1978 - 1991
ICD-O-2 Morphology
9671/3
Effective 1992 - 2000
ICD-O-3 Morphology
9671/3
Effective 2001 and later
Reportable
for cases diagnosed 1978 and later
Primary Site(s)
See Abstractor Notes and Module 7

Help me code for diagnosis year :

Grade
6 - B-cell
Module Rule
Module 6: PH17
Alternate Names
Immunocytoma [OBS]
LPL
Malignant lymphoma, lymphoplasmacytic
Malignant lymphoma, lymphoplasmacytoid
Malignant lymphoma, plasmacytoid [OBS]
Plasmacytic lymphoma [OBS]
Definition
Neoplasm of small B lymphocytes, plasmacytoid lymphocytes, and plasma cells, usually involving bone marrow, lymph nodes, spleen; usually lacking CD5; serum monoclonal protein of IgM in most cases with consequent hyperviscosity symptoms.
Abstractor Notes
Most cases of lympholasmacytic lymphoma (LPL) involve the bone marrow; some cases have involvement of lymph nodes and/or organs. Peripheral blood may be involved.

LPL is an NOS; both Waldenstrom macroglobulinemia and Gamma heavy chain disease are variants of LPL. All three diseases are diagnosed by an increased number of immunoglobulins. WM is caused by increased lymphocytes which causes an increase in IgM. Gamma heavy chain disease is caused by increased plasma cells which results in an increase of IgG. LPL has mixed abnormalities, both the lymphocytes and plasma cells are increased which results in an abnormally high IgM AND IgG.

Waldenstrom Macroglobulinemia (WM) is a subset of LPL; WM has its own code (9761/3). See the abstractor notes for WM for more information.

Gamma heavy chain disease (9762/3) is a variant of LPL, since it has it's own code, use the specific code 9767/3. See the abstractor notes for Gamma heavy chain disease for more information.
Definitive Diagnostic Methods
Bone Marrow biopsy
Histological confirmation
Peripheral blood
Genetics Data
None
Immunophenotyping
IgA positive
IgG positive
IgM monclonal gammopathy positive
Treatments
Chemotherapy
Hormone
Transformations from
No Transformations
Corresponding ICD-9 Codes
200.8 Other named variants, lymphoma
Corresponding ICD-10 Codes
C83.0 Diffuse non-Hodgkin's disease, small cell (diffuse)
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C83.0 Small cell B-cell lymphoma
Signs and Symptoms
None
Diagnostic Exams
None
Recurrence and Metastases
None
Epidemiology and Mortality
None