Primary mediastinal (thymic) large B-cell lymphoma

Name
Primary mediastinal (thymic) large B-cell lymphoma
ICD-O-3 Morphology
9679/3
Effective 2001 and later
Reportable
for cases diagnosed 2001 and later
Primary Site(s)
C379, C383

Help me code for diagnosis year :

Grade
6 - B-cell
Module Rule
None
Alternate Names
Med-DLBCL
Mediastinal large B-cell lymphoma
PMBL
Thymic large B-cell lymphoma
Definition
Subtype of diffuse Large B-Cell lymphoma, large transformed cells resembling centroblasts or immunoblasts, relatively abundant pale cytoplasm often with distinct cytoplasmic membrane; apparently derived from thymus medullary B cells, may occur as secondary malignancy following nodular sclerosing Hodgkin lymphoma.
Abstractor Notes
Code the primary site to C379 (thymus) or C383 (mediastinum) based on the physician's statement. For either thymus or mediastinal primaries, the mediastinal and cervical lymph nodes may be involved.

PMBL most likely arises within the thymus. Patients present with a localized antereosuperior mediastinal mass. The mass is often bulky and frequently invades adjacent structures such as lungs, pleura, or pericardium. Spread to supraclavicular and cervical LN can occur. This is a diffuse large B-cell lymphoma arising in the mediastinum from putative thymic B-cell origin with distinctive clinical immunophenotypic and genotypic feature that allow a diagnosis to be confirmed on a small amount of tissues.
Definitive Diagnostic Methods
Genetic testing
Histological confirmation
Immunophenotype
Genetics Data
Comparative genomic hybridzation (CH) demonstrated gains in chromosome 9p24 and 2p15
Genomic hybridization in chromosome X-11.4-21
Immunophenotyping
CD19+
CD20+
CD22+
CD30 weakly positive and heterogeneous
CD79a+
Lacks immunoglobulin (Ig)
Treatments
Chemotherapy
Radiation
Transformations to
No Transformations
Transformations from
No Transformations
Corresponding ICD-9 Codes
200.7 Large cell lymphoma
Corresponding ICD-10 Codes
C83.3 Diffuse non-Hodgkins lymphoma, large cell (diffuse)
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C85.2 Mediastinal (thymic) large B-cell lymphoma
Signs and Symptoms
None
Diagnostic Exams
None
Recurrence and Metastases
None
Epidemiology and Mortality
None